Following strong activation signals, several types of immune cells reportedly release
chromatin and granular proteins into the extracellular space, forming DNA traps. This …

Complement activation in the diseases paroxysmal nocturnal hemoglobinuria (PNH) and
atypical hemolytic uremic syndrome (aHUS) results in cytolysis and fatal thrombotic events …

Two major aspects of systemic lupus erythematosus (SLE) pathogenesis that have yet to be
targeted therapeutically are immune complex-initiated complement activation and neutrophil …

The EPICC peptides are a family of peptides that have been developed from the sequence
of the capsid protein of human astrovirus type 1 and previously shown to inhibit the classical …

Myeloperoxidase is the major peroxidase enzyme in neutrophil granules and implicated in
contributing to inflammatory lung damage in cystic fibrosis. Free myeloperoxidase is present …

Hemoglobin is the natural carrier of oxygen in red blood cells (RBCs). While intracellular
hemoglobin provides life‐sustaining oxygen transport, extracellular free hemoglobin …

Reactive oxygen species (ROS) are natural byproducts of oxidative respiration that are toxic
to organs and tissues. To mitigate ROS damage, organisms have evolved a variety of …

The assembly of tissue-damaging membrane attack complexes (MACs; C5b–9) is a major
mechanism by which excessive complement activation causes diseases. We previously …

The complement system is one of the body's major innate immune defense mechanisms in
vertebrates. Its function is to detect foreign bodies and promote their elimination through …

A 14-year-old female patient with sickle cell disease developed a severe delayed hemolytic
transfusion reaction (DHTR) leading to multiple transfusions and intensive care …