The Japanese clinical practice guidelines for management of sepsis and septic shock 2020 (J-SSCG 2020)
M Egi, H Ogura, T Yatabe, K Atagi, S Inoue, T Iba… - Journal of intensive …, 2021 - Springer
Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …
Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société …
R Guilhaumou, S Benaboud, Y Bennis… - Critical Care, 2019 - Springer
Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …
[HTML][HTML] Optimizing antibiotic therapies to reduce the risk of bacterial resistance
S Bassetti, S Tschudin-Sutter, A Egli… - European journal of …, 2022 - Elsevier
The incidence of infections caused by bacteria that are resistant to antibiotics is constantly
increasing. In Europe alone, it has been estimated that each year about 33′ 000 deaths are …
increasing. In Europe alone, it has been estimated that each year about 33′ 000 deaths are …
Surviving sepsis campaign: research priorities for sepsis and septic shock
CM Coopersmith, D De Backer, CS Deutschman… - Intensive care …, 2018 - Springer
Objective To identify research priorities in the management, epidemiology, outcome and
underlying causes of sepsis and septic shock. Design A consensus committee of 16 …
underlying causes of sepsis and septic shock. Design A consensus committee of 16 …
Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: a systematic review and meta-analysis of randomised trials
KZ Vardakas, GL Voulgaris, A Maliaros… - The Lancet infectious …, 2018 - thelancet.com
Background The findings of randomised controlled trials (RCT), observational studies, and
meta-analyses vary regarding the effectiveness of prolonged β-lactam infusion. We aimed to …
meta-analyses vary regarding the effectiveness of prolonged β-lactam infusion. We aimed to …
Continuous versus intermittent β-lactam infusion in severe sepsis. A meta-analysis of individual patient data from randomized trials
Rationale: Optimization of β-lactam antibiotic dosing for critically ill patients is an intervention
that may improve outcomes in severe sepsis. Objectives: In this individual patient data meta …
that may improve outcomes in severe sepsis. Objectives: In this individual patient data meta …
Continuous vs intermittent meropenem administration in critically ill patients with sepsis: the MERCY randomized clinical trial
Importance Meropenem is a widely prescribed β-lactam antibiotic. Meropenem exhibits
maximum pharmacodynamic efficacy when given by continuous infusion to deliver constant …
maximum pharmacodynamic efficacy when given by continuous infusion to deliver constant …
Extended-infusion β-lactam therapy, mortality, and subsequent antibiotic resistance among hospitalized adults with gram-negative bloodstream infections
SM Karaba, SE Cosgrove, JH Lee, S Fiawoo… - JAMA Network …, 2024 - jamanetwork.com
Importance Current evidence is conflicting for associations of extended-infusion β-lactam (EI-
BL) therapy with clinical outcomes. Objective To investigate the association of EI-BL therapy …
BL) therapy with clinical outcomes. Objective To investigate the association of EI-BL therapy …
International consensus recommendations for the use of prolonged‐infusion beta‐lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British …
Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …
Therapeutic drug monitoring of β-lactam antibiotics in the critically ill: direct measurement of unbound drug concentrations to achieve appropriate drug exposures
G Wong, S Briscoe, B McWhinney, M Ally… - Journal of …, 2018 - academic.oup.com
Objectives To describe the achievement of unbound β-lactam antibiotic concentration
targets in a therapeutic drug monitoring (TDM) programme in critically ill patients, and the …
targets in a therapeutic drug monitoring (TDM) programme in critically ill patients, and the …