There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

The objective of this article is to present a broad review of the role of cardiac electric rotors
and their accompanying spiral waves in the mechanism of cardiac fibrillation. At the outset …

Aims To report 5-year outcomes of EFFORTLESS registry patients with early generation
subcutaneous implantable cardioverter-defibrillator (S-ICD) devices. Methods and results …

Ca2+ plays a crucial role in connecting membrane excitability with contraction in
myocardium. The hallmark features of heart failure are mechanical dysfunction and …

Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …

Although sinus node dysfunction (SND) and atrial arrhythmias frequently coexist and
interact, the putative mechanism linking the 2 remain unclear. Although SND is …

Aims Mapping data of human ventricular fibrillation (VF) are limited. We performed detailed
mapping of the activities underlying the onset of VF and targeted ablation in patients with …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Atrial fibrillation (AF) is an extremely prevalent arrhythmia that presents a wide range of
therapeutic challenges. AF usually begins in a self-terminating paroxysmal form (pAF). With …

Physiological variability manifests itself via differences in physiological function between
individuals of the same species, and has crucial implications in disease progression and …