Short linear motifs (SLiMs) are a unique and ubiquitous class of protein interaction modules
that perform key regulatory functions and drive dynamic complex formation. For decades …

Biological processes are dynamically regulated by signaling networks composed of protein
kinases and phosphatases. Calcineurin, or PP3, is a conserved phosphoserine …

Specific protein–protein interactions are central to all processes that underlie cell
physiology. Numerous studies have together identified hundreds of thousands of human …

Viral proteins make extensive use of short peptide interaction motifs to hijack cellular host
factors. However, most current large-scale methods do not identify this important class of …

Alzheimer's disease (AD) is characterized by an early, asymptomatic phase (AsymAD) in
which individuals exhibit amyloid-beta (Aβ) plaque accumulation in the absence of clinically …

The recent revolution in computational protein structure prediction provides folding models
for entire proteomes, which can now be integrated with large-scale experimental data. Mass …

Large-scale mining and analysis of bacterial datasets contribute to the comprehensive
characterization of complex microbial dynamics within a microbiome and among different …

Membrane contact sites (MCS) are intracellular regions where two organelles come closer
to exchange information and material. The majority of the endoplasmic reticulum (ER) MCS …

Short linear motifs (SLiMs) drive dynamic protein-protein interactions essential for signaling,
but sequence degeneracy and low binding affinities make them difficult to identify. We …

Summary PP1 and PP2A-B56 are major serine/threonine phosphatase families that achieve
specificity by colocalizing with substrates. At the kinetochore, however, both phosphatases …