Synapses are intercellular junctions specialized for fast, point-to-point information transfer
from a presynaptic neuron to a postsynaptic cell. At a synapse, a presynaptic terminal …

Developing neurons connect in specific and stereotyped ways to form the complex circuits
that underlie brain function. By comparison to earlier steps in neural development, progress …

Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we
define a molecular interaction between neurons and microglia that drives experience …

The ability of cells to organize into multicellular structures in precise patterns requires that
they" recognize" one another with high specificity. We discuss recent progress in …

Synapse organizing proteins are multifaceted molecules that coordinate the complex
processes of brain development and plasticity at the level of individual synapses. Their …

In the developing human brain, only 53 stochastically expressed clustered protocadherin
(cPcdh) isoforms enable neurites from individual neurons to recognize and self-avoid while …

Distinct neuronal types connect in complex ways to generate functional neural circuits. The
molecular diversity required to specify this connectivity could be supplied by multigene …

Advances in genomics are opening new windows into the biology of schizophrenia. Though
common variants individually have small effects on disease risk, GWAS provide a powerful …

The development of a functional nervous system entails establishing connectivity between
appropriate synaptic partners. During axonal pathfinding, the developing axon navigates …

The regulation of synaptic strength forms the basis of learning and memory, and is a key
factor in understanding neuropathological processes that lead to cognitive decline and …