Experimental chemotherapy-induced mucositis: a scoping review guiding the design of suitable preclinical models

J Huang, AYM Hwang, Y Jia, B Kim, M Iskandar… - International Journal of …, 2022 - mdpi.com
Mucositis is a common and most debilitating complication associated with the cytotoxicity of
chemotherapy. The condition affects the entire alimentary canal from the mouth to the anus …

Animal models of chemotherapy-induced mucositis: translational relevance and challenges

PT Sangild, RL Shen… - American Journal of …, 2018 - journals.physiology.org
Chemotherapy for cancer patients induces damaging tissue reactions along the epithelium
of the gastrointestinal tract (GIT). This chemotherapy-induced mucositis (CIM) is a serious …

Alteration of gut microbiota and inflammatory cytokine/chemokine profiles in 5-fluorouracil induced intestinal mucositis

HL Li, L Lu, XS Wang, LY Qin, P Wang… - Frontiers in cellular …, 2017 - frontiersin.org
Disturbed homeostasis of gut microbiota has been suggested to be closely associated with 5-
fluorouracil (5-Fu) induced mucositis. However, current knowledge of the overall profiles of 5 …

[HTML][HTML] Berberine regulates fecal metabolites to ameliorate 5-fluorouracil induced intestinal mucositis through modulating gut microbiota

H Chen, F Zhang, R Li, Y Liu, X Wang, X Zhang… - Biomedicine & …, 2020 - Elsevier
Berberine (BBR) is an isoquinoline alkaloid, which has been used in the treatment of
intestinal mucositis. However, BBR on chemotherapy-induced mucositis in cancer patients …

A rodent model of human-dose-equivalent 5-fluorouracil: toxicity in the liver, kidneys, and lungs

MC da Silva, LC Fabiano, KC da Costa Salomão… - Antioxidants, 2023 - mdpi.com
5-Fluorouracil (5-FU) is a chemotherapy drug widely used to treat a range of cancer types,
despite the recurrence of adverse reactions. Therefore, information on its side effects when …

l-Glutamine and l-arginine protect against enterotoxigenic Escherichia coli infection via intestinal innate immunity in mice

G Liu, W Ren, J Fang, CAA Hu, G Guan, NA Al-Dhabi… - Amino acids, 2017 - Springer
Dietary glutamine (Gln) or arginine (Arg) supplementation is beneficial for intestinal health;
however, whether Gln or Arg may confer protection against Enterotoxigenic Escherichia coli …

Protective effects of Oxyberberine in 5‐fluorouracil‐induced intestinal mucositis in the mice model

R Huang, G Ai, L Zhong, L Mai, JN Chen… - Evidence‐Based …, 2022 - Wiley Online Library
Berberine (BBR), a major active constituent of Rhizoma coptidis, was reported to exert
beneficial effects on intestinal mucositis (IM) induced by 5‐fluorouracil (5‐FU). However, the …

Secretion of biologically active pancreatitis-associated protein I (PAP) by genetically modified dairy Lactococcus lactis NZ9000 in the prevention of intestinal mucositis

RD Carvalho, N Breyner, Z Menezes-Garcia… - Microbial Cell …, 2017 - Springer
Background Mucositis is one of the most relevant gastrointestinal inflammatory conditions in
humans, generated by the use of chemotherapy drugs, such as 5-fluoracil (5-FU). 5-FU …

The intestinal redox system and its significance in chemotherapy‐induced intestinal mucositis

QQ Yu, H Zhang, Y Guo, B Han… - Oxidative Medicine and …, 2022 - Wiley Online Library
Chemotherapy‐induced intestinal mucositis (CIM) is a significant dose‐limiting adverse
reaction brought on by the cancer treatment. Multiple studies reported that reactive oxygen …

Evaluating the mucoprotective effects of glycyrrhizic acid-loaded polymeric nanoparticles in a murine model of 5-fluorouracil-induced intestinal mucositis via …

M Zeeshan, A Atiq, QU Ain, J Ali, S Khan, H Ali - Inflammopharmacology, 2021 - Springer
Abstract Objectives 5-Fluorouracil (5-FU), a chemotherapeutic drug, has severe
deteriorating effects on the intestine, leading to mucositis. Glycyrrhizic acid is a compound …