DNA is one of the most fascinating biopolymers. Besides its central role as carrier of genetic
information and translation of the genetic code into proteins, DNA holds great promise as a …

Development of DNA biosensors and DNA microarrays has increased tremendously over
the past few years as demonstrated by the large number of scientific publications in this area …

The ability to monitor drugs, metabolites, hormones, and other biomarkers in situ in the body
would greatly advance both clinical practice and biomedical research. To this end, we are …

Fçrster (or fluorescence) resonance energy transfer (FRET) involves the nonradiative
transfer of excitation energy from an excited donor fluorophore, D,(after absorption of a …

A bifunctional derivative of the thrombin-binding aptamer with a redox-active Fc moiety and
a thiol group at the termini of the aptamer strand was synthesized. The ferrocene-labeled …

Organometallic chemistry and biochemistry have been merged in the last two decades into a
new field: bioorganometallic chemistry. This new research area was devoted to the …

As viruses constantly change due to mutation, variants are expected to emerge demanding
development of sensors capable of detecting multiple variants using one single sensor …

A systematic study of the amplified optical detection of DNA by Mg2+-dependent DNAzyme
subunits is described. The use of two DNAzyme subunits and the respective …

An enzyme-free amplified detection platform is described using the horseradish peroxidase
(HRP)-mimicking DNAzyme as an amplifying label. Two hairpin structures that include three …

Methods for real-time, high-sensitivity polynucleotide detection are of vast scientific and
economic importance. Homogeneous biosensor assays that take advantage of the collective …