Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention
Scientists have long sought to characterize the pathophysiologic basis of schizophrenia and
develop biomarkers that could identify the illness. Extensive postmortem and in vivo …
develop biomarkers that could identify the illness. Extensive postmortem and in vivo …
Dendritic spines in depression: what we learned from animal models
H Qiao, MX Li, C Xu, HB Chen, SC An… - Neural plasticity, 2016 - Wiley Online Library
Depression, a severe psychiatric disorder, has been studied for decades, but the underlying
mechanisms still remain largely unknown. Depression is closely associated with alterations …
mechanisms still remain largely unknown. Depression is closely associated with alterations …
The hippocampus in aging and disease: from plasticity to vulnerability
T Bartsch, P Wulff - Neuroscience, 2015 - Elsevier
The hippocampus has a pivotal role in learning and in the formation and consolidation of
memory and is critically involved in the regulation of emotion, fear, anxiety, and stress …
memory and is critically involved in the regulation of emotion, fear, anxiety, and stress …
A pathophysiological framework of hippocampal dysfunction in ageing and disease
The hippocampal formation has been implicated in a growing number of disorders, from
Alzheimer's disease and cognitive ageing to schizophrenia and depression. How can the …
Alzheimer's disease and cognitive ageing to schizophrenia and depression. How can the …
[HTML][HTML] Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver
The hippocampus in schizophrenia is characterized by both hypermetabolism and reduced
size. It remains unknown whether these abnormalities are mechanistically linked. Here we …
size. It remains unknown whether these abnormalities are mechanistically linked. Here we …
Neuroinflammation and neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease
Recent human trials of treatments for Alzheimer's disease (AD) have been largely
unsuccessful, raising the idea that treatment may need to be started earlier in the disease …
unsuccessful, raising the idea that treatment may need to be started earlier in the disease …
Hippocampal and amygdalar volume changes in major depressive disorder: a targeted review and focus on stress
M Nolan, E Roman, A Nasa, KJ Levins… - Chronic …, 2020 - journals.sagepub.com
Medial temporal lobe structures have long been implicated in the pathogenesis of major
depressive disorder. Although findings of smaller hippocampal and amygdalar volumes are …
depressive disorder. Although findings of smaller hippocampal and amygdalar volumes are …
Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction
Schizophrenia is characterized by reduced hippocampal volume, decreased dendritic spine
density, altered neuroplasticity signaling pathways, and cognitive deficits associated with …
density, altered neuroplasticity signaling pathways, and cognitive deficits associated with …
Neuroprotective function for ramified microglia in hippocampal excitotoxicity
J Vinet, HRJ van Weering, A Heinrich, RE Kälin… - Journal of …, 2012 - Springer
Background Most of the known functions of microglia, including neurotoxic and
neuroprotective properties, are attributed to morphologically-activated microglia. Resting …
neuroprotective properties, are attributed to morphologically-activated microglia. Resting …
Progression from selective to general involvement of hippocampal subfields in schizophrenia
NF Ho, JE Iglesias, MY Sum, CN Kuswanto… - Molecular …, 2017 - nature.com
Volume deficits of the hippocampus in schizophrenia have been consistently reported.
However, the hippocampus is anatomically heterogeneous; it remains unclear whether …
However, the hippocampus is anatomically heterogeneous; it remains unclear whether …