Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for
vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with …

Deciphering the secret of successful aging depends on understanding the patterns and
biological underpinnings of cognitive and behavioral changes throughout adulthood. That …

Background An increased rate of brain atrophy is often observed in older subjects, in
particular those who suffer from cognitive decline. Homocysteine is a risk factor for brain …

ABSTRACT The Hordaland Homocysteine Study (HHS) is a population-based study of more
than 18,000 men and women in the county of Hordaland in Western Norway. The first …

Background A high circulating concentration of the amino acid homocysteine is an
independent risk factor for stroke. Alzheimer's disease (AD) commonly co-occurs with stroke …

Background: Elevated homocysteine concentrations may contribute to cognitive impairment.
Most elevations in homocysteine result from inadequate folate, vitamin B-12, or vitamin B-6 …

Background Evidence supports an independent association between plasma total
homocysteine concentrations and the risk of vascular disease. Recent epidemiologic studies …

Vitamin B12 is a cofactor of methionine synthase in the synthesis of methionine, the
precursor of the universal methyl donor S-Adenosylmethionine (SAMe), which is involved in …

A number of well-designed epidemiological studies have linked type 2 diabetes mellitus
(T2DM) with an increased risk of Alzheimer's disease (AD). Several mechanisms could help …

Dementia has reached epidemic proportions, with an estimated 4.6 million new cases
worldwide each year. With an aging world population, the prevalence of dementia will …