Soil-transmitted helminth vaccines: are we getting closer?

A Zawawi, KJ Else - Frontiers in immunology, 2020 - frontiersin.org
Parasitic helminths infect over one-fourth of the human population resulting in significant
morbidity, and in some cases, death in endemic countries. Despite mass drug administration …

Immunoinformatics driven construction of multi-epitope vaccine candidate against Ascaris lumbricoides using its entire immunogenic epitopes

R Kaur, N Arora, SS Rawat, AK Keshri… - Expert Review of …, 2021 - Taylor & Francis
Objective Ascaris lumbricoides infects 80 million people per year, causing malnutrition,
stunted growth of children etc., but there is no vaccine available against it. We aimed to …

In silico design of a polypeptide as a vaccine candidate against ascariasis

FMD Evangelista, AHM van Vliet, SP Lawton… - Scientific reports, 2023 - nature.com
Ascariasis is the most prevalent zoonotic helminthic disease worldwide, and is responsible
for nutritional deficiencies, particularly hindering the physical and neurological development …

A reverse vaccinology approach identifies putative vaccination targets in the zoonotic nematode Ascaris

FMD Evangelista, AHM van Vliet, SP Lawton… - Frontiers in veterinary …, 2022 - frontiersin.org
Ascariasis is the most prevalent helminthic disease affecting both humans and pigs and is
caused by the roundworms Ascaris lumbricoides and Ascaris suum. While preventive …

[HTML][HTML] Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids

AJ Wolstenholme, EC Andersen… - Advances in …, 2024 - ncbi.nlm.nih.gov
The ascarids are a large group of parasitic nematodes that infect a wide range of animal
species. In humans, they cause neglected diseases of poverty; many animal parasites also …

Recent Advances in Parasitomics: Omics in the Study of Ascariasis

NL Tang, JE Weatherhead - … in Parasitomics: Implications for Parasite and …, 2025 - Springer
Ascaris is the most common helminth infection in the world, leading to significant global
morbidity. Despite the high burden of disease globally, ascariasis remains widely …

[PDF][PDF] RESEARCH ARTICLE Preliminary studies on the effect of excretory secretory (ES) Ascaris lumbricoides antigens on colorectal cell line viability

NN Ab Talib, M Nisha, R Ramasamy… - Tropical …, 2024 - psasir.upm.edu.my
Helminth parasites are a group of complex metazoans from various taxonomic families.
Excretory secretory (ES) by-products, secreted by living parasites from the surface …

Effective assessment of CD4+ T cell Immunodominance patterns: impact of antigen processing and HLA restriction

M Alvaro-Benito, ET Abualrous, H Lingel, S Meltendorf… - bioRxiv, 2024 - biorxiv.org
Identifying T cell epitopes is essential for studying and potentially tuning immune responses
to pathogens. The polymorphic nature of major histocompatibility complex of class II (MHCII) …

CD4+ T Cell Epitope Identification from Complex Parasite Antigen Mixtures

M Álvaro-Benito, F Ebner, M Bertazzon… - Computational Vaccine …, 2023 - Springer
Antigen complexity represents a major challenge for scoring CD4+ T cell immunogenicity, a
key hallmark of immunity and with great potential to improve vaccine development. In this …

[HTML][HTML] Vacunas parasitarias: del tratamiento a la prevención

ACM de Oca, TR Cruz-Hernández - medvacunas.com
Las vacunas constituyen una de las principales estrategias de protección contra diversas
enfermedades virales y algunas bacterianas; sin embargo, en el ámbito de la lucha contra …