Anxiety disorders are the most prevalent psychiatric disorders and a leading cause of
disability. While there continues to be expansive research in posttraumatic stress disorder …

Tremendous progress has been made in basic neuroscience in recent decades. One area
that has been especially successful is research on how the brain detects and responds to …

Background Anxiety and related disorders are among the most common mental disorders,
with lifetime prevalence reportedly as high as 31%. Unfortunately, anxiety disorders are …

Major depressive disorder is a common psychiatric disorder associated with marked
suffering, morbidity, mortality, and cost. The World Health Organization projects that by 2030 …

The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …

Research on the neural substrates of drug reward, withdrawal and relapse has yet to be
translated into significant advances in the treatment of addiction. One potential reason is that …

Introduction: Anxiety disorders are among the most prevalent and disabling psychiatric
disorders in the United States and worldwide. Basic research has provided critical insights …

Anxiety disorders are common, serious and a growing health problem worldwide. However,
the causative factors, aetiology and underlying mechanisms of anxiety disorders, as for most …

Abstract Background Dr. Athina Markou sought treatments for a common neural substrate
shared by depression and drug dependence. Antagonists of corticotropin-releasing factor …

Addictive disorders are partly heritable, chronic, relapsing conditions that account for a
tremendous disease burden. Currently available addiction pharmacotherapies are only …