Abstract RNA polymerase II (RNA Pol II) speed or elongation rate, ie, the number of
nucleotides synthesized per unit of time, is a major determinant of transcriptome …

The concept of probiotics is witnessing increasing attention due to its benefits in influencing
the host microbiome and the modulation of host immunity through the strengthening of the …

Epitranscriptomic features, such as single-base RNA editing, are sources of transcript
diversity in cancer, but little is understood in terms of their spatial context in the tumour …

A wealth of single-cell protocols makes it possible to characterize different molecular layers
at unprecedented resolution. Integrating the resulting multimodal single-cell data to find cell …

Alternative polyadenylation (APA) plays an important role in posttranscriptional gene
regulation such as transcript stability and translation efficiency. However, our knowledge …

Single-cell technologies have transformed biomedical research over the last decade,
opening up new possibilities for understanding cellular heterogeneity, both at the genomic …

Multidrug-resistant (MDR) Pseudomonas aeruginosa infections pose a significant challenge
to effective treatment. Although carbapenems were once considered the primary therapeutic …

Single-cell research has provided a breakthrough in biology to understand heterogeneous
cell groups, such as tissues and organs, in development and disease. Molecular barcoding …

Five-prime single-cell RNA-seq (scRNA-seq) has been widely employed to profile cellular
transcriptomes, however, its power of analysing transcription start sites (TSS) has not been …

Motivation The advent of multi-modal single-cell sequencing techniques have shed new
light on molecular mechanisms by simultaneously inspecting transcriptomes, epigenomes …