Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs

X Zhang, H Xing, Y Zhao, Z Ma - Pharmaceutics, 2018 - mdpi.com
Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …

Enhancement of ketoprofen dissolution rate by the liquisolid technique: Optimization and in vitro and in vivo investigations

S Devi, S Kumar, V Verma, D Kaushik, R Verma… - Drug Delivery and …, 2022 - Springer
The objective of the current study is to evaluate the prospective of liquisolid formulation to
improve the dissolution rate of ketoprofen and thereby the bioavailability. Different batches …

Formulation and evaluation of Loperamide HCl oro dispersible tablets

B Alejandro, T Guillermo, PM Ángeles - Pharmaceuticals, 2020 - mdpi.com
This work proposes the design of novel oral disintegrating tablets (ODTs) of loperamide HCl
with special emphasis on disintegration and dissolution studies. The main goal was …

Liquisolid Technique: A Novel Technique with Remarkable Applications in Pharmaceutics

S Singh, J Singh, D Arora - Current Drug Discovery …, 2024 - ingentaconnect.com
Recently, it has been observed that newly developed drugs are lipophilic and have low
aqueous solubility issues, which results in a lower dissolution rate and bioavailability of the …

Whole whey stabilized oleanolic acid nanosuspension: Formulation and evaluation study

NB Banarase, CD Kaur - Journal of Drug Delivery Science and Technology, 2022 - Elsevier
Oleanolic acid (OA), an important natural product, bears variety of pharmacological actions
of interest; but its use in the modern therapy is limited due to low water solubility and …

Spectrophotometric Determination of Loperamide Hydrochloride by Ion-Pair Formation with Rose Bengal Reagent

MW Sabr, DS Ali, S Smaoui, JM Lorenzo - Food Analytical Methods, 2023 - Springer
A simple and accurate spectrophotometric technique has been presented for determining
the presence of loperamide hydrochloride. The approach involves forming an ion-pair …

[PDF][PDF] Design and evaluation of liquisolid compacts of nebivolol hydrochloride

RS Sura, C Subrahmanyam, SS Rachamalla - Int. J. Appl. Pharm, 2022 - academia.edu
Objective: The aim of this study was to investigate the potential of a liquisolid system to
improve the dissolution rate and the bioavailability of nebivolol hydrochloride. Methods …

[PDF][PDF] Neusilin based liquisolid compacts of albendazole: Design, development, characterization and in vitro anthelmintic activity

A Shete, A Salunkhe, A Yadav, S Sakhare, R Doijad - J. Res. Pharm, 2019 - jrespharm.com
The present investigation deals with enhancement of dissolution rate of high dose drug
albendazole (ABZ) using liquisolid compacts. Study of precompression characteristics …

Design and Development of Solid SMEDDS and Liquisolid Formulations of Lovastatin, for Improved Drug Dissolution and In vivo Effects—a Pharmacokinetic and …

D Suram, K Veerabrahma - AAPS PharmSciTech, 2022 - Springer
Lovastatin (Lov) is a lipid-lowering agent, with 5% bioavailability (BA) due to extensive first
pass metabolism and poor solubility. To enhance dissolution and in vivo effects, Lov solid …

Digital image disintegration analysis: A novel quality control method for fast disintegrating tablets

O Malallah, Z Rashid, CL Li, A Alqurshi… - AAPS …, 2021 - Springer
Measuring tablet disintegration is essential for quality control purposes; however, no
established method adequately accounts for the timeframe or small volumes of the medium …