Neurobiologic Advances from the Brain Disease Model of Addiction | New England Journal of
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Early adolescent substance use dramatically increases the risk of lifelong substance use
disorder (SUD). An adolescent sensitive period evolved to allow the development of risk …

This review examines neuroimaging and neurocognitive findings on alcohol-related toxicity
in adolescents. Teens who meet criteria for alcohol use disorders, as well as those who …

This article reviews the neurocognitive and neuroimaging literature regarding the effect of
alcohol use on human adolescent brain structure and function. Adolescents who engage in …

Sensation-seeking (SS) is a personality trait that refers to individual differences in motivation
for intense and unusual sensory experiences. It describes a facet of human behaviour that …

Imaging genetics offers the possibility of detecting associations between genotype and brain
structure as well as function, with effect sizes potentially exceeding correlations between …

Drug addiction is widely recognized to afflict some but not all individuals by virtue of
underlying risk markers and traits involving multifaceted interactions between polygenic and …

We propose that structural and functional connectivity of the anterior cingulate cortex (ACC)
represents a critical component of adolescent developmental psychopathology. We …

Novelty-seeking tendencies in adolescents may promote innovation as well as problematic
impulsive behaviour, including drug abuse. Previous research has not clarified whether …

ADHD is a disorder characterized by changes in the reward system and which is highly
comorbid with other mental disorders, suggesting common neurobiological pathways …