Proteomics continues to forge significant strides in the discovery of essential biological
processes, uncovering valuable information on the identity, global protein abundance …

The ECM (extracellular matrix) is a major component of the vascular microenvironment that
modulates vascular homeostasis. ECM proteins include collagens, elastin, noncollagen …

Proteolysis, an irreversible post-translational modification catalyzed by proteases, plays a
crucial role in various biological processes. Exploring abnormally hydrolyzed proteins in …

State‐of‐the‐art mass spectrometers combined with modern bioinformatics algorithms for
peptide‐to‐spectrum matching (PSM) with robust statistical scoring allow for more variable …

The N‐termini of proteins can regulate their degradation, and the same protein with different
N‐termini may have distinct dynamics. Recently, it was found that N‐terminal glycine can …

Protein N‐and C‐termini have specific biochemical properties and functions. They play vital
roles in various biological processes, such as protein stability and localization. In addition …

Limited proteolysis, called protein processing, is an essential post-translational mechanism
that controls protein localization, activity, and in consequence, function. This process is …

Aberrant levels of the asparaginyl endopeptidase legumain have been linked to
inflammation, neurodegeneration, and cancer, yet our understanding of this protease is …

The main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) plays a crucial role in its life cycle. The Mpro-mediated limited proteolysis of the viral …

Bovine pancreatic trypsin was crystallized, in‐complex with Lima bean trypsin inhibitor
(LBTI)(Phaseolus lunatus L.), in the form of a ternary complex. LBTI is a Bowman–Birk‐type …