Restenosis, defined as the re-narrowing of an arterial lumen after revascularization,
represents an increasingly important issue in clinical practice. Indeed, as the number of stent …

Diabetes mellitus (DM) is a chronic metabolic disease caused by a complex interaction of
genetic and environmental factors and is characterized by persistent hyperglycemia. Long …

Background: Frailty is a multidimensional condition often diagnosed in older adults with
hypertension and diabetes, and both these conditions are associated with endothelial …

OBJECTIVE To assess whether the sodium–glucose cotransporter 2 (SGLT2) inhibitor
empagliflozin improves cognitive impairment in frail older adults with diabetes and heart …

Endothelial dysfunction represents a key mechanism underlying heart failure with preserved
ejection fraction (HFpEF), diabetes mellitus (DM), and frailty. However, reliable biomarkers …

Oxidative stress and endothelial dysfunction have been shown to play crucial roles in the
pathophysiology of COVID-19 (coronavirus disease 2019). On these grounds, we sought to …

Background Diabetes and hypertension are common in older adults and represent
established risk factors for frailty. Frailty is a multidimensional condition due to reserve loss …

Background Cardiac fibrosis represents a key element in the pathophysiology of heart
failure with preserved ejection fraction (HFpEF), a condition highly prevalent amongst …

OBJECTIVE Ischemia with nonobstructive coronary arteries (INOCA) is a prevailing finding
in patients with angina. However, the main factors underlying the risk of being rehospitalized …

Aims Pre-diabetes is a condition that confers an increased cardiovascular risk. Frailty is very
common in hypertensive patients, and insulin resistance has been linked to frailty in older …