Regenerative potential of injured spinal cord in the light of epigenetic regulation and modulation

S Gupta, S Dutta, SP Hui - Cells, 2023 - mdpi.com
A spinal cord injury is a form of physical harm imposed on the spinal cord that causes
disability and, in many cases, leads to permanent mammalian paralysis, which causes a …

MicroRNA-21's role in PTEN suppression and PI3K/AKT activation: Implications for cancer biology

HS Chawra, M Agarwal, A Mishra, SS Chandel… - … -Research and Practice, 2024 - Elsevier
Abstract MicroRNA-21 (miR-21) was recognized as a key figure in the intricate web of tumor
biology, with a prominent role in regulating the PTEN tumor suppressor gene and the …

Electroacupuncture Promotes Nerve Regeneration and Functional Recovery Through Regulating lncRNA GAS5 Targeting miR-21 After Sciatic Nerve Injury

M Tian, Y Yang, W Qin, B Liu, F Mou, J Zhu… - Molecular …, 2024 - Springer
Although the benefits of electroacupuncture (EA) for peripheral nerve injury (PNI) are well
accepted in clinical practice, the underlying mechanism remains incompletely elucidated. In …

MicroRNAs in spinal cord injury: A narrative review

C Zhang, Z Talifu, X Xu, W Liu, H Ke, Y Pan… - Frontiers in Molecular …, 2023 - frontiersin.org
Spinal cord injury (SCI) is a global medical problem with high disability and mortality rates.
At present, the diagnosis and treatment of SCI are still lacking. Spinal cord injury has a …

The regulatory role of miR-21 in ferroptosis by targeting FTH1 and the contribution of microglia-derived miR-21 in exosomes to arsenic-induced neuronal ferroptosis

H Wang, X Liu, Y Chen, W Li, Y Ge, H Liang… - Journal of Hazardous …, 2024 - Elsevier
Arsenic is recognized as a hazardous environmental toxicant strongly associated with
neurological damage, but the mechanism is ambiguous. Neuronal cell death is one of the …

Modulation of immune cum inflammatory pathway by earthworm granulation tissue extract in wound healing of diabetic rabbit model

AME Elkhalifa, SI Ali, SU Nabi, I Bashir, S Taifa… - Heliyon, 2024 - cell.com
Regeneration is a rare occurrence in the animal kingdom, but the earthworm stands out as a
remarkable example of this phenomenon. Recent research has highlighted the promising …

[HTML][HTML] Stem Cell-Derived Extracellular Vesicle-Mediated Therapeutic Signaling in Spinal Cord Injury

R Poongodi, YW Hsu, TH Yang, YH Huang… - International Journal of …, 2025 - mdpi.com
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as a
promising therapeutic strategy for spinal cord injury (SCI). These nanosized vesicles …

[HTML][HTML] The Ambivalent Role of miRNA-21 in Trauma and Acute Organ Injury

A Ritter, J Han, S Bianconi, D Henrich, I Marzi… - International Journal of …, 2024 - mdpi.com
Since their initial recognition, miRNAs have been the subject of rising scientific interest.
Especially in recent years, miRNAs have been recognized to play an important role in the …

Identification of Anoikis-Related Genes in Spinal Cord Injury: Bioinformatics and Experimental Validation

W Yin, Z Jiang, Y Guo, Y Cao, Z Wu, Y Zhou… - Molecular …, 2024 - Springer
Spinal cord injury (SCI) is a serious disease without effective therapeutic strategies. To
identify the potential treatments for SCI, it is extremely important to explore the underlying …

Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury

S Yang, B Yu, Q Zhang, Y Zhang, L Fu, B Zhou… - Journal of Translational …, 2025 - Springer
Background Spinal cord injury (SCI) triggers a complex inflammatory response that impedes
neural repair and functional recovery. The modulation of macrophage phenotypes is thus …