Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum
Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the …

Eukaryotic cells have been confronted throughout their evolution with potentially lethal
plasma membrane injuries, including those caused by osmotic stress, by infection from …

Western blotting is one of the most commonly used laboratory techniques for identifying
proteins and semi-quantifying protein amounts; however, several recent findings suggest …

Repeated, intense use of muscles leads to a decline in performance known as muscle
fatigue. Many muscle properties change during fatigue including the action potential …

Muscle protein breakdown (MPB) is an important metabolic component of muscle
remodeling, adaptation to training, and increasing muscle mass. Degradation of muscle …

Calcium (Ca2+) plays a pivotal role in almost all cellular processes and ensures the
functionality of an organism. In skeletal muscle fibers, Ca2+ is critically involved in the …

Western blotting has been used for protein analyses in a wide range of tissue samples for>
30 years. Fundamental to Western blotting success are a number of important …

Calpains are cysteine proteases expressed in skeletal muscle fibers and other cells.
Although calpain was first reported to act as a kinase activating factor in skeletal muscle, the …

In healthy muscle, the rapid release of calcium ions (Ca2+) with excitation–contraction (EC)
coupling, results in elevations in Ca2+ concentrations which can exceed 10-fold that of …