The activated product of the myc oncogene deregulates both cell growth and death check
points and, in a permissive environment, rapidly accelerates the affected clone through the …

Despite its intensive investigation for almost two decades, c-Myc remains a fascinating and
enigmatic subject. A large and compelling body of evidence indicates that c-Myc is a …

AP-1 (Activating Protein 1) transcription factor activity is tightly regulated at multiple levels,
including dimer formation (ie, Fos/Jun). Here we show that the intermediate filament protein …

Abstract PC4 (pheochromocytoma cell-4) is an immediate early gene related to IFN-gamma,
the mRNA of which is induced during the course of neuronal differentiation by nerve growth …

Import of 'nuclear'proteins into the nucleus, in particular, transcription factors, is not a
constitutive process; instead it appears to be modulated in response to external stimuli, cell …

The glycosylation of serine and threonine residues with beta-O-linked N-acetylglucosamine
(O-GlcNAc) is an abundant posttranslational modification of nuclear and cytoplasmic …

Transcriptional control plays a key role in regulating epidermal proliferation and
differentiation. Although ample information has been obtained on how epidermal …

The transcription factor MYC (also c-Myc) induces histone modification, chromatin
remodeling, and the release of paused RNA polymerase to broadly regulate transcription …

Rationale: Although sepsis-associated encephalopathy (SAE) is a common psychiatric
complication in septic patients, the underlying mechanisms remain unclear. Here, we …

Prefoldin is a cochaperone, present in all eukaryotes, that cooperates with the chaperonin
CCT. It is known mainly for its functional relevance in the cytoplasmic folding of actin and …