Many existing clinical treatments are limited in their ability to completely restore decreased
or lost tissue and organ function, an unenviable situation only further exacerbated by a …

Articular cartilage damage caused by sports injury or osteoarthritis (OA) has gained
increased attention as a worldwide health burden. Pharmaceutical treatments are …

Alterations in the growth and maturation of chondrocytes can lead to variation in human
height, including monogenic disorders of skeletal growth. We aimed to identify genes and …

Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder
leading to end-stage renal disease. ADPKD arises from mutations in the PKD1 and PKD2 …

Osteoarthritis (OA) is a severely painful and debilitating disease of the joint, which brings
about degradation of the articular cartilage and currently has few therapeutic solutions. Two …

Tissue engineered hyaline cartilage is plagued by poor mechanical properties largely due to
inadequate type II collagen expression. Of note, commonly used defined chondrogenic …

Collagen overproduction is a feature of fibrosis and cancer, while insufficient deposition of
functional collagen molecules and/or the secretion of malformed collagen is common in …

In the field of regenerative medicine, optimization of the parameters leading to a desirable
outcome remains a huge challenge. Examples include protocols for the guided …

One of the ligaments most often damaged during sports—the anterior cruciate ligament
(ACL)—has poor healing capacity. On damage, reconstructive surgery is performed to …

Chemical and mechanical cues are well-established influencers of in vitro chondrogenic
differentiation of ATDC5 cells. Here, we investigate the role of topographical cues in this …