Transcriptional architecture of the mammalian circadian clock
JS Takahashi - Nature Reviews Genetics, 2017 - nature.com
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …
behavioural processes in organisms. These cell-autonomous clocks are composed of a …
Bile acid signaling in metabolic disease and drug therapy
T Li, JYL Chiang, Q Ma - Pharmacological reviews, 2014 - Elsevier
Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …
The small molecule nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome
Dysregulation of circadian rhythms is associated with metabolic dysfunction, yet it is unclear
whether enhancing clock function can ameliorate metabolic disorders. In an unbiased …
whether enhancing clock function can ameliorate metabolic disorders. In an unbiased …
New insights into the circadian rhythm and its related diseases
Y Xie, Q Tang, G Chen, M Xie, S Yu, J Zhao… - Frontiers in …, 2019 - frontiersin.org
Circadian rhythms (CR) are a series of endogenous autonomous oscillators generated by
the molecular circadian clock which acting on coordinating internal time with the external …
the molecular circadian clock which acting on coordinating internal time with the external …
[HTML][HTML] Sleep homeostasis and the circadian clock: do the circadian pacemaker and the sleep homeostat influence each other's functioning?
T Deboer - Neurobiology of sleep and circadian rhythms, 2018 - Elsevier
Sleep is regulated by a homeostatic and a circadian process. Together these two processes
determine most aspects of sleep and related variables like sleepiness and alertness. The …
determine most aspects of sleep and related variables like sleepiness and alertness. The …
Circadian integration of metabolism and energetics
J Bass, JS Takahashi - Science, 2010 - science.org
Circadian clocks align behavioral and biochemical processes with the day/night cycle.
Nearly all vertebrate cells possess self-sustained clocks that couple endogenous rhythms …
Nearly all vertebrate cells possess self-sustained clocks that couple endogenous rhythms …
Peroxiredoxins are conserved markers of circadian rhythms
Cellular life emerged∼ 3.7 billion years ago. With scant exception, terrestrial organisms
have evolved under predictable daily cycles owing to the Earth's rotation. The advantage …
have evolved under predictable daily cycles owing to the Earth's rotation. The advantage …
Central and peripheral circadian clocks in mammals
JA Mohawk, CB Green… - Annual review of …, 2012 - annualreviews.org
The circadian system of mammals is composed of a hierarchy of oscillators that function at
the cellular, tissue, and systems levels. A common molecular mechanism underlies the cell …
the cellular, tissue, and systems levels. A common molecular mechanism underlies the cell …
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
The molecular clock maintains energy constancy by producing circadian oscillations of rate-
limiting enzymes involved in tissue metabolism across the day and night,,. During periods of …
limiting enzymes involved in tissue metabolism across the day and night,,. During periods of …
The mammalian circadian timing system: organization and coordination of central and peripheral clocks
C Dibner, U Schibler, U Albrecht - Annual review of physiology, 2010 - annualreviews.org
Most physiology and behavior of mammalian organisms follow daily oscillations. These
rhythmic processes are governed by environmental cues (eg, fluctuations in light intensity …
rhythmic processes are governed by environmental cues (eg, fluctuations in light intensity …