Type IV secretion systems (T4SS) translocate DNA and protein substrates across prokaryotic
cell envelopes generally by a mechanism requiring direct contact with a target cell. Three …

The genus Legionella contains more than 50 species, of which at least 24 have been
associated with human infection. The best-characterized member of the genus, Legionella …

The agent of Q fever, Coxiella burnetii, is an obligate intracellular bacterium that causes
acute and chronic infections. The study of C. burnetii pathogenesis has benefited from two …

Coxiella burnetii, the causative agent of human Q fever, is an intracellular pathogen that
replicates in an acidified vacuole derived from the host lysosomal network. This pathogen …

Central to Q fever pathogenesis is replication of the causative agent, Coxiella burnetii, within
a phagolysosome-like parasitophorous vacuole (PV) in mononuclear phagocytes. C …

Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-derived vacuole.
The molecular mechanisms used by this bacterium to create a pathogen-occupied vacuole …

Legionella and Coxiella are intracellular pathogens that use the virulence-related Icm/Dot
type-IVB secretion system to translocate effector proteins into host cells during infection …

The ankyrin repeat (ANK) is the most common protein–protein interaction motif in nature,
and is predominantly found in eukaryotic proteins. Genome sequencing of various …

Coxiella burnetii is an obligate intracellular bacterial pathogen responsible for acute and
chronic Q fever. This bacterium harbors a type IV secretion system (T4SS) highly similar to …

Many bacterial pathogens employ multicomponent protein complexes to deliver
macromolecules directly into their eukaryotic host cell to promote infection. Some Gram …