To maintain iron homeostasis, fungi have to balance iron acquisition, storage, and utilization
to ensure sufficient supply and to avoid toxic excess of this essential trace element. As …

The synthesis and trafficking of iron-sulfur (Fe-S) clusters in both prokaryotes and
eukaryotes requires coordination within an expanding network of proteins that function in the …

Iron-sulfur (Fe-S) clusters are unique, redox-active co-factors ubiquitous throughout cellular
metabolism. Fe-S cluster synthesis, trafficking, and coordination result from highly …

Despite the number of cellular and pathological mitoNEET-related processes, very few
details are known about the mechanism of action of the protein. The recently discovered …

CISD3 is a mitochondrial protein belonging to the NEET proteins family, bearing two [Fe 2 S
2] clusters coordinated by CDGSH domains. At variance with the other proteins of the NEET …

Cancer cells preferentially accumulate iron (Fe) relative to non-malignant cells; however, the
underlying rationale remains elusive. Iron–sulfur (Fe–S) clusters are critical cofactors that …

Fe-S clusters are essential cofactors for the activity of a large variety of metalloproteins that
play important roles in respiration, photosynthesis, nitrogen fixation, regulation of gene …

The biogenesis of iron–sulfur (Fe/S) proteins entails the synthesis and trafficking of Fe/S
clusters, followed by their insertion into target apoproteins. In eukaryotes, the multiple steps …

Size Exclusion Chromatography coupled with Multi-Angle Light Scattering (SEC-MALS) is a
technique that determines the absolute molar mass (molecular weight) of macromolecules in …

Abstract [4Fe‐4S] 2+ cluster assembly in human cytosol requires both a [2Fe‐2S] cluster
chaperone being able to donate two [2Fe‐2S] 2+ clusters and an electron donor providing …