Molecular regulations of circadian rhythm and implications for physiology and diseases
The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
[HTML][HTML] Broad targeting of angiogenesis for cancer prevention and therapy
Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …
is a main driving force in many severe human diseases including cancer. As such, tumor …
Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma
Glioblastoma (GBM) is one of the most aggressive tumors in the adult central nervous
system. We previously revealed that circadian regulation of glioma stem cells (GSCs) affects …
system. We previously revealed that circadian regulation of glioma stem cells (GSCs) affects …
TNFR1 mediates TNF-α-induced tumour lymphangiogenesis and metastasis by modulating VEGF-C-VEGFR3 signalling
Inflammation and lymphangiogenesis are two cohesively coupled processes that promote
tumour growth and invasion. Here we report that TNF-α markedly promotes tumour …
tumour growth and invasion. Here we report that TNF-α markedly promotes tumour …
Circadian clock-mediated control of stem cell division and differentiation: beyond night and day
SA Brown - Development, 2014 - journals.biologists.com
A biological 'circadian'clock conveys diurnal regulation upon nearly all aspects of behavior
and physiology to optimize them within the framework of the solar day. From digestion to …
and physiology to optimize them within the framework of the solar day. From digestion to …
Relationship between oxidative stress, circadian rhythms, and AMD
ML Fanjul-Moles… - Oxidative Medicine and …, 2016 - Wiley Online Library
This work reviews concepts regarding oxidative stress and the mechanisms by which
endogenous and exogenous factors produce reactive oxygen species (ROS). It also surveys …
endogenous and exogenous factors produce reactive oxygen species (ROS). It also surveys …
A zebrafish model discovers a novel mechanism of stromal fibroblast-mediated cancer metastasis
C Liu, Y Zhang, S Lim, K Hosaka, Y Yang… - Clinical Cancer …, 2017 - AACR
Purpose: Cancer metastasis can occur at the early stage of tumor development when a
primary tumor is at the microscopic size. In particular, the interaction of malignant cells with …
primary tumor is at the microscopic size. In particular, the interaction of malignant cells with …
The role of circadian clock genes in tumors
HX Li - OncoTargets and therapy, 2019 - Taylor & Francis
Circadian rhythms are generated via variations in the expression of clock genes that are
organized into a complex transcriptional–translational autoregulatory network and regulate …
organized into a complex transcriptional–translational autoregulatory network and regulate …
A comprehensive rhythmicity analysis of host proteins and immune factors involved in malaria pathogenesis to decipher the importance of host circadian clock in …
Background Circadian rhythms broadly impact human health by regulating our daily
physiological and metabolic processes. The circadian clocks substantially regulate our …
physiological and metabolic processes. The circadian clocks substantially regulate our …
Selective IKK2 inhibitor IMD0354 disrupts NF-κB signaling to suppress corneal inflammation and angiogenesis
A Lennikov, P Mirabelli, A Mukwaya, M Schaupper… - Angiogenesis, 2018 - Springer
Corneal neovascularization is a sight-threatening condition caused by angiogenesis in the
normally avascular cornea. Neovascularization of the cornea is often associated with an …
normally avascular cornea. Neovascularization of the cornea is often associated with an …