To protect our body systems, there is a constant interactive conversation between the skin
nervous and immune system. Important elements of this conversation in the skin include …

Alternative splicing of the precursor mRNA encoding for the neuropeptide receptor
PAC1/ADCYAP1R1 generates multiple protein products that exhibit pleiotropic activities …

Pain is a common annoying non-motor symptom in Parkinson's disease (PD) that causes
distress to patients. Treatment for PD pain remains a big challenge, as its underlying …

Synaptic plasticity is defined as the ability of synapses to change their strength of
transmission. Plasticity of synaptic connections in the brain is a major focus of neuroscience …

The adrenomedullary chromaffin cell transduces chemical messages into outputs that
regulate end organ function throughout the periphery. At least two important …

Pituitary adenylyl cyclase activating polypeptide (PACAP) was originally isolated from the
hypothalamus and found to stimulate adenylyl cyclase in the pituitary. Later studies showed …

It has been shown that prostaglandin (PG) E2 synthesized in the lateral parabrachial
nucleus (LPBN) is involved in lipopolysaccharide-induced fever. But the neural mechanisms …

Repetitive hypoxia is a key feature of obstructive sleep apnoea (OSA), a condition
characterized by intermittent airways obstruction. Patients with OSA present with persistent …

The peristaltic contraction and relaxation of intestinal circular and longitudinal smooth
muscles is controlled by synaptic circuit elements that impinge upon phenotypically diverse …

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide
found at synapses throughout the central and autonomic nervous system. We previously …