Neuroinflammatory mechanisms of mitochondrial dysfunction and neurodegeneration in glaucoma

JN Duarte - Journal of Ophthalmology, 2021 - Wiley Online Library
The exact mechanism of retinal ganglion cell loss in the pathogenesis of glaucoma is yet to
be understood. Mitochondrial damage‐associated molecular patterns (DAMPs) resulting …

Visual system manifestations of Alzheimer's disease

Y Kusne, AB Wolf, K Townley, M Conway… - Acta …, 2017 - Wiley Online Library
Alzheimer's disease (AD) is an increasingly common disease with massive personal and
economic costs. While it has long been known that AD impacts the visual system, there has …

Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice

JR Tribble, JM Harder, PA Williams, SWM John - Molecular brain, 2020 - Springer
Glaucoma is the leading cause of irreversible vision loss. Ocular hypertension is a major risk
factor for glaucoma and recent work has demonstrated critical early neuroinflammatory …

Quantitative assessment of the retina using OCT and associations with cognitive function

Y Ito, M Sasaki, H Takahashi, S Nozaki, S Matsuguma… - Ophthalmology, 2020 - Elsevier
Purpose To determine the association of retinal thickness with cognitive function in
Japanese persons. Design Cross-sectional, population-based survey. Participants A total of …

Association of retinal nerve fiber layer thickness with brain alterations in the visual and limbic networks in elderly adults without dementia

JL Méndez-Gómez, A Pelletier, MB Rougier… - JAMA network …, 2018 - jamanetwork.com
Importance The eye is a sensory organ that is easily accessible for imaging techniques,
allowing the measurement of the retinal nerve fiber layer (RNFL) thickness. The eye is part …

Associations between vision impairment and eye diseases with dementia, dementia subtypes and cognitive impairment: An umbrella review

M Rahmati, L Smith, H Lee, L Boyer, G Fond… - Ageing Research …, 2024 - Elsevier
Vision impairment (VI) and eye diseases such as age-related macular degeneration (AMD),
diabetic retinopathy (DR), glaucoma and cataract have been reported to be associated with …

How strong is the relationship between glaucoma, the retinal nerve fibre layer, and neurodegenerative diseases such as Alzheimer's disease and multiple sclerosis?

E Jones-Odeh, CJ Hammond - Eye, 2015 - nature.com
Glaucoma is a neurodegenerative disorder with established relationships with ocular
structures such as the retinal nerve fibre layer (RNFL) and the ganglion cell layer (GCL) …

Association between glaucoma and the risk of dementia

CW Su, CC Lin, CH Kao, HY Chen - Medicine, 2016 - journals.lww.com
Association Between Glaucoma and the Risk of Dementia : Medicine Association Between
Glaucoma and the Risk of Dementia : Medicine Log in or Register Get new issue alertsGet …

Association between glaucoma and the risk of Alzheimer's disease: a systematic review of observational studies

XH Xu, JY Zou, W Geng, AY Wang - Acta Ophthalmologica, 2019 - Wiley Online Library
To address inconsistency as well as investigate the relationship between glaucoma and the
risk of Alzheimer's disease (AD). We systematically conducted this meta‐analysis based on …

Protein and imaging biomarkers in the eye for early detection of Alzheimer's disease

S Fereshetian, JS Agranat, N Siegel… - Journal of …, 2021 - content.iospress.com
Alzheimer's disease (AD) is one of the most common causes of dementia worldwide.
Although no formal curative therapy exists for the treatment of AD, considerable research …