[HTML][HTML] The chemistry of snake venom and its medicinal potential

AL Oliveira, MF Viegas, SL da Silva… - Nature Reviews …, 2022 - nature.com
The fascination and fear of snakes dates back to time immemorial, with the first scientific
treatise on snakebite envenoming, the Brooklyn Medical Papyrus, dating from ancient Egypt …

[HTML][HTML] Biomedical applications of snake venom: From basic science to autoimmunity and rheumatology

CA Cañas, S Castaño-Valencia… - Journal of translational …, 2021 - Elsevier
Snake venoms have components with diverse biological actions that are extensively studied
to identify elements that may be useful in biomedical sciences. In the field of autoimmunity …

Three-Dimensionally Printed Ti2448 With Low Stiffness Enhanced Angiogenesis and Osteogenesis by Regulating Macrophage Polarization via Piezo1/YAP …

Z Tang, X Wei, T Li, H Wu, X Xiao, Y Hao… - Frontiers in Cell and …, 2021 - frontiersin.org
Previous studies have found that the novel low-elastic-modulus Ti2448 alloy can
significantly reduce stress shielding and contribute to better bone repair than the …

Disintegrin-like protein strategy to inhibit aggressive triple-negative breast cancer

I Limam, M Abdelkarim, M El Ayeb, M Crepin… - International journal of …, 2023 - mdpi.com
Venoms are a rich source of bioactive compounds, and among them is leberagin-C (Leb-C),
a disintegrin-like protein derived from the venom of Macrovipera lebetina …

[HTML][HTML] Alternagin-C (ALT-C), a disintegrin-like protein, attenuates alpha2beta1 integrin and VEGF receptor 2 signaling resulting in angiogenesis inhibition

PK Dos Santos, WF Altei, TM Danilucci, RLB Lino… - Biochimie, 2020 - Elsevier
Angiogenesis, a crucial process in tumor progression, is mainly regulated by vascular
endothelial growth factor (VEGF) and its receptor, VEGFR2. Studies have shown the …

The role of snake venom disintegrins in Angiogenesis

PB Clissa, MS Della-Casa, BC Zychar, SS Sanabani - Toxins, 2024 - mdpi.com
Angiogenesis, the formation of new blood vessels, plays a critical role in various
physiological and pathological conditions. Snake venom disintegrins (SVDs) have been …

[HTML][HTML] Bicistronic Vector Expression of Recombinant Jararhagin-C and Its Effects on Endothelial Cells

KF Ferraz, LH De Lucca Caetano, DP Orefice… - Toxins, 2024 - mdpi.com
Jararhagin-C (JarC) is a protein from the venom of Bothrops jararaca consisting of
disintegrin-like and cysteine-rich domains. JarC shows a modulating effect on angiogenesis …

[HTML][HTML] Application of the Sponge Model Implants in the Study of Vaccine Memory in Mice Previously Immunized with LBSap

MF Lanna, LA Resende, PM De Luca, WM Goes… - Vaccines, 2024 - mdpi.com
Background/Objectives: Considering the large number of candidates in vaccine-testing
studies against different pathogens and the amount of time spent in the preclinical and …

Proteogenomic approaches for snake venom protein-based drug development: current trends and challenges

SK Jhade, K Kalidoss, PK Pathak… - Transactions of The …, 2025 - academic.oup.com
Snake venom proteins have long been recognized for their therapeutic potential.
Proteogenomic strategies, integrating transcriptomics and proteomics, have emerged as …

Hormetic-like dose-response induced by alternagin-C, a protein isolated from urutu snake (Rhinocerophis alternatus) venom, in fish (Hoplias malabaricus) cardiac …

DA Monteiro, AL Kalinin, HS Selistre-de-Araujo… - Toxicon, 2022 - Elsevier
The aim of this study was to evaluate the effects of different doses of alternagin-C, a
disintegrin-like protein from Rhinocerophis alternatus venom, on myocardial contractility of …