[HTML][HTML] Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer

Z Hang, T Lei, Z Zeng, S Cai, W Bi, H Du - Biomedicine & Pharmacotherapy, 2022 - Elsevier
An increasing number of epidemiological studies have shown that there is a significant
inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) …

[HTML][HTML] Human endogenous retroviruses as gene expression regulators: insights from animal models into human diseases

S Durnaoglu, SK Lee, J Ahnn - Molecules and cells, 2021 - Elsevier
The human genome contains many retroviral elements called human endogenous
retroviruses (HERVs), resulting from the integration of retroviruses throughout evolution …

Drug discovery inspired by bioactive small molecules from nature

S Kim, SW Lim, J Choi - Animal Cells and Systems, 2022 - Taylor & Francis
Natural products (NPs) have greatly contributed to the development of novel treatments for
human diseases such as cancer, metabolic disorders, and infections. Compared to synthetic …

Comparison of the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress

B Hukkamlı, B Dağdelen, F Sönmez Aydın… - Cell Biochemistry and …, 2023 - Springer
This study was conducted to compare the efficacy of the mouse hepatic and renal
antioxidant systems against inflammation-induced oxidative stress. Increased Il-1 and Il-6 …

Effects of Decursin and Angelica gigas Nakai Root Extract on Hair Growth in Mouse Dorsal Skin via Regulating Inflammatory Cytokines

TK Lee, B Kim, DW Kim, JH Ahn, H Sim, JC Lee… - Molecules, 2020 - mdpi.com
This current study investigates the facilitative effects and mechanisms of decursin, a major
component of Angelica gigas Nakai (AGN), and AGN root extract on hair growth in mice. We …

Gut barrier dysfunction and bacterial lipopolysaccharides in colorectal cancer

Q Li, V von Ehrlich-Treuenstätt, J Schardey… - Journal of …, 2023 - Springer
Background Inflammation is known to be an essential driver of various types of cancer. An
increasing number of studies have suggested that the occurrence and development of …

The Role of Natural Products from Herbal Medicine in TLR4 Signaling for Colorectal Cancer Treatment

Y Luo, G Zhang, C Hu, L Huang, D Wang, Z Chen… - Molecules, 2024 - mdpi.com
The toll-like receptor 4 (TLR4) signaling pathway constitutes an intricate network of protein
interactions primarily involved in inflammation and cancer. This pathway triggers …

MKP-3 suppresses LPS-induced inflammatory responses in HUVECs via inhibition of p38 MAPK/NF-κB pathway

B Unenkhuu, DB Kim, HS Kim - Animal Cells and Systems, 2021 - Taylor & Francis
Endothelial cell dysfunction and inflammatory responses play critical roles in the
development of atherosclerosis. Recent data on the processes underlying atherogenesis …

Melittin-derived peptides exhibit variations in cytotoxicity and antioxidant, anti-inflammatory and allergenic activities

H Jung, YS Kim, DM Jung, KS Lee, JM Lee… - Animal Cells and …, 2022 - Taylor & Francis
Melittin is a major component of bee venom; it is widely used in traditional medicine
because of its therapeutic effects, such as anti-inflammatory effects. However, melittin has …

Mechanisms of lipopolysaccharides-driven progression and metastasis of colorectal cancer

M Zhang, K Liu - 2024 - authorea.com
Colorectal cancer (CRC) is one of the most common malignant tumors in the world, and
enhanced intestinal permeability is the most common pathological phenomenon in CRC …