Molecular genetic approaches in small model organisms like Drosophila have helped to
elucidate fundamental principles of neuronal cell biology. Much less is understood about …

Midbrain dopamine neurons deteriorate in Parkinson's disease (PD) that is a progressive
neurodegenerative movement disorder. No cure is available that would stop the …

INTRODUCTION Regenerative therapies based on cell replacement hold promise for the
treatment of a range of age-related degenerative diseases but are limited by unfavorable …

Glial cells constitute without any dispute an essential element in providing an efficiently
operating nervous system. Work in many labs over the last decades has demonstrated that …

Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived
neurotrophic factor (MANF) promote the survival of midbrain dopaminergic neurons which …

Neurotrophic factors are promising candidates for the treatment of Parkinson's disease (PD).
Mesencephalic astrocyte-derived neurotrophic factor (MANF) belongs to a novel …

All forms of diabetes mellitus (DM) are characterized by the loss of functional pancreatic β
cell mass, leading to insufficient insulin secretion. Thus, identification of novel approaches to …

Current therapeutic interventions for neurodegenerative diseases alleviate only disease
symptoms, while treatments that could stop or reverse actual degenerative processes are …

Background Neurotrophic factors are endogenous proteins promoting the survival of
different neural cells. Therefore, they elicited great interest as a possible treatment for …

This review annotates and categorises the glia of adult Drosophila and other model insects
and analyses the developmental origins of these in the Drosophila optic lobe. The functions …