One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Neurotrophins are a family of proteins that regulate neuronal survival, synaptic function, and
neurotransmitter release, and elicit the plasticity and growth of axons within the adult central …

Spinal cord injury (SCI) often causes severe and permanent disabilities due to the
regenerative failure of severed axons. Here we report significant locomotor recovery of both …

Despite the essential role of the corticospinal tract (CST) in controlling voluntary movements,
successful regeneration of large numbers of injured CST axons beyond a spinal cord lesion …

Interest in BDNF as an activity-dependent modulator of neuronal structure and function in
the adult brain has intensified in recent years. Localization of BDNF-TrkB to glutamate …

Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully
restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have …

Neurotrophins regulate neuronal survival, differentiation, and synaptic function. To
understand how neurotrophins elicit such diverse responses, we elucidated signaling …

The release of glutamate during brain anoxia or ischaemia triggers the death of neurons,
causing mental or physical handicap. The mechanism of glutamate release is controversial …

For many decades, the inability of lesioned central neurons to regrow was accepted almost
as a" law of nature", and on the clinical level, spinal cord and brain lesions were seen as …

Contact-dependent axon growth inhibitory activity is present in CNS myelin, but the
inhibitory proteins have not been fully characterized. We report here that at least two peaks …