Since the discovery of SNARE proteins in the late 1980s, SNAREs have been recognized as
key components of protein complexes that drive membrane fusion. Despite considerable …

Rab proteins constitute the largest branch of the Ras GTPase superfamily. Rabs use the
guanine nucleotide-dependent switch mechanism common to the superfamily to regulate …

Autophagic and endocytic pathways are tightly regulated membrane rearrangement
processes that are crucial for homeostasis, development and disease. Autophagic cargo is …

Neurotransmitter release is governed by proteins that have homo-logs in most types of
intracellular membrane fusion, including the Sec1/Munc18 protein Munc18-1 and the …

The fusion of transport vesicles with their target membranes is fundamental for intracellular
membrane trafficking and diverse physiological processes and is driven by the assembly of …

Both SM proteins (for Sec1/Munc18-like proteins) and SNARE proteins (for soluble NSF-
attachment protein receptors) are essential for intracellular membrane fusion, but the …

Protein trafficking within eukaryotic cells depends on vesicular carriers that fuse with
organelles to deliver their lipid and protein content. Cells have developed an elaborate …

The dynamic equilibrium between vesicle fission and fusion at Golgi, endosome, and
vacuole/lysosome is critical for the maintenance of organelle identity. It depends, among …

Genetic studies in yeast, plants, insects, and mammals have identified four universally
conserved proteins, together called Vps Class C, that are essential for late endosome and …

Coupling of Rab GTPase activation and SNARE complex assembly during membrane fusion
is poorly understood. The homotypic fusion and vacuole protein sorting (HOPS) complex …