Second harmonic generation (SHG) and third harmonic generation (THG) microscopies
have emerged as powerful imaging modalities to examine structural properties of a wide …

This review presents the changes that the imaging of articular cartilage has undergone
throughout the last decades. It highlights that the expectation is no longer to image the …

Type II collagen fibril diameters in cartilage are beneath the diffraction limit of optical
microscopy, which makes the assessment of collagen organization very challenging. In this …

Osteoarthritis (OA) is characterized by the progressive deterioration of articular cartilage,
involving complicated cell-matrix interactions. Systematic investigations of dynamic cellular …

In this study, we extend on the three parameter analysis approach of utilizing a noninvasive
dual-liquid–crystal-based polarization-resolved second harmonic generation (SHG) …

Extensive remodeling of the extracellular matrix (ECM) occurs in many epithelial cancers.
For example, in ovarian cancer, upregulation of collagen isoform type III has been linked to …

Purpose: Imaging-based metrics for analysis of biological tissues are powerful tools that can
extract information such as shape, size, periodicity, and many other features to assess the …

Osteoarthritis (OA) remains a prevalent disease affecting more than 20% of the global
population, resulting in morbidity and lower quality of life for patients. The study of OA …

Background Articular osteochondrosis is a common cause of leg weakness in pigs and is
defined as a focal delay in the endochondral ossification of the epiphysis. The first …

Background Lateral elbow tendinopathy (LET) is a common condition affecting adults.
Although a lack of treatment consensus continues to prompt numerous effectiveness studies …