The cyclic AMP-responsive element-binding protein (CREB) is phosphorylated in response
to a wide variety of signals, yet target gene transcription is only increased in a subset of …

In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …

When energy supply is low, organisms respond by slowing aging and increasing resistance
to diverse age-related pathologies. Targeting the mechanisms underpinning this response …

Hedgehog signalling is crucial for development and is deregulated in several tumours,
including medulloblastoma. Regulation of the transcriptional activity of Gli (glioma …

Mutations in the LKB1 (also known as STK11) tumor suppressor are the third most frequent
genetic alteration in non–small cell lung cancer (NSCLC). LKB1 encodes a serine/threonine …

Background Alternative polyadenylation (APA) is emerging as a major post-transcriptional
mechanism for gene regulation, and dysregulation of APA contributes to several human …

No effective systemic treatment is available for patients with unresectable, recurrent, or
metastatic mucoepidermoid carcinoma (MEC), the most common salivary gland malignancy …

Background The epigenetic mechanisms involved in the progression of pancreatic ductal
adenocarcinoma (PDAC) remain largely unexplored. This study aimed to identify key …

The brain has the ability to sense, coordinate, and respond to environmental changes
through biological processes involving activity-dependent gene expression. cAMP-response …

Hedgehog pathway regulates tissue patterning and cell proliferation. Gli1 transcription factor
is the major effector of Hedgehog signaling and its deregulation is often associated to …