Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …

Although the core concept of remyelination—based on the activation, migration, proliferation
and differentiation of CNS progenitors—has not changed over the past 20 years, our …

Diffuse white-matter disease associated with small-vessel disease and dementia is
prevalent in the elderly. The biological mechanisms, however, remain elusive. Using …

Myelination of axons in the nervous system of vertebrates enables fast, saltatory impulse
propagation, one of the best-understood concepts in neurophysiology. However, it took a …

Heart valve disease is a serious and growing public health problem for which prosthetic
replacement is most commonly indicated. Current prosthetic devices are inadequate for …

Multiple sclerosis is characterized by inflammatory activity that results in destruction of the
myelin sheaths that enwrap axons. The currently available medications for multiple sclerosis …

Oligodendrocytes associate with axons to establish myelin and provide metabolic support to
neurons. In the spinal cord of amyotrophic lateral sclerosis (ALS) mice, oligodendrocytes …

Axons are electrically excitable, cable-like neuronal processes that relay information
between neurons within the nervous system and between neurons and peripheral target …

Highlights•Myelin is an insulator that can shield long axons from rapid access to
metabolites.•Oligodendrocytes can 'feed'axons with glycolysis products such as …

Injury to the central nervous system (CNS) results in oligodendrocyte cell death and
progressive demyelination. Demyelinated axons undergo considerable physiological …