The physical stability of solid-state forms in which drugs may exist is in some sense an
overlooked aspect. In an era where strategies such as amorphous solid dispersions or co …

Thermogravimetric analysis (TGA) is frequently used to define the threshold of acceptable
processing temperatures for hot melt extrusion. Herein, evaluation of chemical stability of …

The amorphous form of a drug can greatly improve the solubility and rates of dissolution for
enhancing oral bioavailability. However, amorphous drugs tend to crystallize thus negating …

In recent decades, solid dispersions have been demonstrated as an effective approach for
improving the bioavailability of poorly water-soluble drugs, as have solid dispersion …

One of the challenges in developing three-dimensional printed medicines is related to their
stability due to the manufacturing conditions involving high temperatures. This work …

The effect of cooling on the degree of crystallinity, solid-state and dissolution properties of
multi-component hot-melt extruded solid dispersions [SD] is of great interest for the …

Here, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug
products for the first time. For this, a combined mixture design was employed using …

Fenbendazole (fen) or methyl N-(6-phenylsulfanyl-1 H-benzimidazol-2-yl) carbamate is a
broad-spectrum anthelmintic from the class of organic compounds known as …

Metastable forms and amorphous forms exhibit higher solubility and dissolution rates
compared to stable crystalline forms, making them viable options for pharmaceuticals with …

The most common drawback of the existing and novel drug molecules is their low
bioavailability because of their low solubility. One of the most important approaches to …