Human immune diversity: from evolution to modernity
The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
Making human immune systems more interpretable through systems immunology
The human immune system is a distributed system of specialized cell populations with
unique functions that collectively give rise to immune responses to infections and during …
unique functions that collectively give rise to immune responses to infections and during …
Baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology
RC Mettelman, A Souquette, LA Van de Velde… - Nature …, 2023 - nature.com
Evidence suggests that innate and adaptive cellular responses mediate resistance to the
influenza virus and confer protection after vaccination. However, few studies have resolved …
influenza virus and confer protection after vaccination. However, few studies have resolved …
Systems-level immunomonitoring from acute to recovery phase of severe COVID-19
Severe disease of SARS-CoV-2 is characterized by vigorous inflammatory responses in the
lung, often with a sudden onset after 5–7 days of stable disease. Efforts to modulate this …
lung, often with a sudden onset after 5–7 days of stable disease. Efforts to modulate this …
Biomonitoring and precision health in deep space supported by artificial intelligence
Human exploration of deep space will involve missions of substantial distance and duration.
To effectively mitigate health hazards, paradigm shifts in astronaut health systems are …
To effectively mitigate health hazards, paradigm shifts in astronaut health systems are …
Integration of molecular profiles in a longitudinal wellness profiling cohort
An important aspect of precision medicine is to probe the stability in molecular profiles
among healthy individuals over time. Here, we sample a longitudinal wellness cohort with …
among healthy individuals over time. Here, we sample a longitudinal wellness cohort with …
Next generation plasma proteome profiling to monitor health and disease
The need for precision medicine approaches to monitor health and disease makes it
important to develop sensitive and accurate assays for proteome profiles in blood. Here, we …
important to develop sensitive and accurate assays for proteome profiles in blood. Here, we …
The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery
Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening disease
occurring several weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
occurring several weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint
Multimodal single-cell profiling methods can capture immune cell variations unfolding over
time at the molecular, cellular, and population levels. Transforming these data into biological …
time at the molecular, cellular, and population levels. Transforming these data into biological …
Pre‐vaccination immunotypes reveal weak and robust antibody responders to influenza vaccination
A Cevirgel, SA Shetty, M Vos, NM Nanlohy… - Aging …, 2024 - Wiley Online Library
Effective vaccine‐induced immune responses are particularly essential in older adults who
face an increased risk of immunosenescence. However, the complexity and variability of the …
face an increased risk of immunosenescence. However, the complexity and variability of the …