Aging drives the genetic and epigenetic changes that result in a decline in hematopoietic
stem cell (HSC) functioning. Such changes lead to aging-related hematopoietic/immune …

Cystic fibrosis (CF) pathophysiology is hallmarked by excessive inflammation and the
inability to efficiently resolve lung infections, contributing to morbidly and eventually the …

The adult immune system consists of cells that emerged at various times during ontogeny.
We aimed to define the relationship between developmental origin and composition of the …

B2 cells engage in classical antibody responses, whereas B1 cells are considered carriers
of innate immunity, biased toward recognizing epitopes present on the surfaces of common …

Human B-lymphopoiesis is a dynamic life-long process that starts in utero by around six post-
conception weeks. A detailed understanding of human fetal B-lymphopoiesis and how it …

Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma with poor long-term overall
survival. Currently, MCL research and development of potential cures is hampered by the …

Historically, the immune system was believed to develop along a linear axis of maturity from
fetal life to adulthood. Now, it is clear that distinct layers of immune cells are generated from …

The origin and function of blood IgM+ IgD+ CD27+ B cells is controversial, and they are
considered a heterogeneous population. Previous staining of circulating B cells of healthy …

Due to ontogenetic changes in B‐cell developmental lineages, the mature B‐cell
compartment constitutes by functionally different B‐cell subsets that emerged from prenatal …

Developing B cells can be positively or negatively selected by self-antigens, but the
mechanisms that determine these outcomes are incompletely understood. Here, we show …