Clinical studies have demonstrated that a single sub-anesthetic dose of the dissociative
anesthetic ketamine induces rapid and sustained antidepressant actions. Although this …

The efficacy of standard antidepressants is limited for many patients with mood disorders
such as major depressive disorder (MDD) and bipolar depression, underscoring the urgent …

In this review, we highlight the current understanding of translation elongation and recoding
in eukaryotes. In addition to providing an overview of the process, recent advances in our …

Activity-dependent changes in the strength of synaptic connections are fundamental to the
formation and maintenance of memory. The mechanisms underlying persistent changes in …

Traditional pharmacological treatments for depression have a delayed therapeutic onset,
ranging from several weeks to months, and there is a high percentage of individuals who …

Eukaryotic elongation factor 2 kinase (eEF2K) is a member of the small group of atypical 'α-
kinases'. It phosphorylates and inhibits eukaryotic elongation factor 2, to slow down the …

Regulation of protein synthesis makes a major contribution to post-transcriptional control
pathways. During disease, or under stress, cells initiate processes to reprogramme protein …

Background: The most recurrent and considered second most frequent cause of cancer-
related deaths worldwide in women is the breast cancer. The key to diagnosis is early …

Translational control in neurons is crucially required for long-lasting changes in synaptic
function and memory storage. The importance of protein synthesis control to brain processes …

There is accumulating evidence demonstrating that dysfunction of glutamatergic
neurotransmission, particularly via N-methyl-d-aspartate (NMDA) receptors, is involved in …