Biology and biomechanics of the heart valve extracellular matrix
KM Kodigepalli, K Thatcher, T West… - Journal of …, 2020 - mdpi.com
Heart valves are dynamic structures that, in the average human, open and close over
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …
Matters of the heart: cellular sex differences
Nearly all cardiovascular diseases show sexual dimorphisms in prevalence, presentation,
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …
Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics
Abstract 3D culture of cells in designer biomaterial matrices provides a biomimetic cellular
microenvironment and can yield critical insights into cellular behaviours not available from …
microenvironment and can yield critical insights into cellular behaviours not available from …
Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts
Fibrotic disease is caused by the continuous deposition of extracellular matrix by persistently
activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury …
activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury …
4D printing of extrudable and degradable poly (ethylene glycol) microgel scaffolds for multidimensional cell culture
Granular synthetic hydrogels are useful bioinks for their compatibility with a variety of
chemistries, affording printable, stimuli‐responsive scaffolds with programmable structure …
chemistries, affording printable, stimuli‐responsive scaffolds with programmable structure …
Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling
Aortic valve stenosis (AVS) is a progressive fibrotic disease that is caused by thickening and
stiffening of valve leaflets. At the cellular level, quiescent valve interstitial cells (qVICs) …
stiffening of valve leaflets. At the cellular level, quiescent valve interstitial cells (qVICs) …
Transforming growth factor-β1 promotes fibrosis but attenuates calcification of valvular tissue applied as a three-dimensional calcific aortic valve disease model
A Jenke, J Kistner, S Saradar… - American Journal …, 2020 - journals.physiology.org
Calcific aortic valve disease (CAVD) is characterized by valvular fibrosis and calcification
and driven by differentiating valvular interstitial cells (VICs). Expression data from patient …
and driven by differentiating valvular interstitial cells (VICs). Expression data from patient …
Dissecting calcific aortic valve disease—the role, etiology, and drivers of valvular fibrosis
Calcific aortic valve disease (CAVD) is a highly prevalent and progressive disorder that
ultimately causes gradual narrowing of the left ventricular outflow orifice with ensuing …
ultimately causes gradual narrowing of the left ventricular outflow orifice with ensuing …
Tumor necrosis factor‐α promotes and exacerbates calcification in heart valve myofibroblast populations
A Gonzalez Rodriguez, ME Schroeder… - The FASEB …, 2021 - Wiley Online Library
Pro‐inflammatory cytokines play critical roles in regulating valvular interstitial cell (VIC)
phenotypic changes that can cause heart valve fibrosis and calcification. Tumor necrosis …
phenotypic changes that can cause heart valve fibrosis and calcification. Tumor necrosis …
Collagen networks within 3D PEG hydrogels support valvular interstitial cell matrix mineralization
Enzymatically degradable hydrogels were designed for the 3D culture of valvular interstitial
cells (VICs), and through the incorporation of various functionalities, we aimed to investigate …
cells (VICs), and through the incorporation of various functionalities, we aimed to investigate …