A series of recent discoveries harnessing the adaptive immune system of prokaryotes to
perform targeted genome editing is having a transformative influence across the biological …

The clustered regularly interspaced short palindromic repeats (CRISPR) renaissance was
catalysed by the discovery that RNA-guided prokaryotic CRISPR-associated (Cas) proteins …

Abstract The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and
Jennifer Doudna for the development of the Clustered regularly interspaced short …

Experimental evidence accumulated over decades has implicated epithelial–mesenchymal
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …

Increasing clinical evidence has demonstrated that the deletion or mutation of tumor
suppressor genes such as the gene-encoding phosphatase and tensin homolog deleted on …

In the United States, breast cancer is among the most frequently diagnosed cancers in
women. Breast cancer is classified into four major subtypes: human epidermal growth factor …

Highlights•TNBC represents the most aggressive phenotype of breast cancer.•Conventional
therapy prescribed for breast cancer is not effective in treatment of TNBC.•Specific …

Cancer is one of the major causes of mortality worldwide, therefore it is considered a major
health concern. Breast cancer is the most frequent type of cancer which affects women on a …

The gene editing tool CRISPR-Cas has become the foundation for developing numerous
molecular systems used in research and, increasingly, in medical practice. In particular, Cas …

Cancer development involves both genetic and epigenetic alterations. Aberrant epigenetic
modifications are reversible, allowing excellent opportunities for therapeutic intervention …