Glucagon-Like Peptides | Endocrine Reviews | Oxford Academic Skip to Main Content
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The incretin hormone GLP1 promotes islet-cell survival via the second messenger cAMP.
Here we show that mice deficient in the activity of CREB, caused by expression of a …

Differentiated pancreatic β cells are unique in their ability to secrete insulin in response to a
rise in plasma glucose. We have proposed that the unique constellation of genes they …

Numerous members of the nuclear hormone receptor (NR) superfamily have been
demonstrated to regulate metabolic function in a cell-and tissue-specific manner. This …

Peptide hormones are secreted from endocrine cells and neurons and exert their actions
through activation of G protein-coupled receptors to regulate a diverse number of …

Dipeptidyl peptidase IV (DP-IV), a member of the prolyl oligopeptidase family of peptidases,
is involved in the metabolic inactivation of a glucose-dependent insulinotropic hormone …

We previously provided evidence that glucagon-like peptide 1 (GLP-1) induces pancreatic β-
cell growth nonadditively with glucose in a phosphatidylinositol (PI) 3-kinase-and protein …

Background Physical activity may be associated with reduced risk of colorectal cancer. The
main aim of this paper is to review the available evidence for a link between exercise and …

Aims/hypothesis. Glucagon-like peptide-1 is a potent glucoincretin hormone and a
potentially important drug in the treatment of Type II (non-insulin-dependent) diabetes …

Aims/hypothesis We have provided evidence that glucagon-like peptide-1, a potential
therapeutic agent in the treatment of diabetes, activates phosphatidylinositol-3 …