Kisspeptins and reproduction: physiological roles and regulatory mechanisms
L Pinilla, E Aguilar, C Dieguez, RP Millar… - Physiological …, 2012 - journals.physiology.org
Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …
have evolved to mediate the diverse internal and external environmental inputs that regulate …
AgRP to Kiss1 neuron signaling links nutritional state and fertility
Mammalian reproductive function depends upon a neuroendocrine circuit that evokes the
pulsatile release of gonadotropin hormones (luteinizing hormone and follicle-stimulating …
pulsatile release of gonadotropin hormones (luteinizing hormone and follicle-stimulating …
Epigenetic control of female puberty
A Lomniczi, A Loche, JM Castellano… - Nature …, 2013 - nature.com
The timing of puberty is controlled by many genes. The elements coordinating this process
have not, however, been identified. Here we show that an epigenetic mechanism of …
have not, however, been identified. Here we show that an epigenetic mechanism of …
High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons
Kisspeptin (Kiss1) and neurokinin B (NKB) neurocircuits are essential for pubertal
development and fertility. Kisspeptin neurons in the hypothalamic arcuate nucleus …
development and fertility. Kisspeptin neurons in the hypothalamic arcuate nucleus …
MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons
The identification of loss-of-function mutations in MKRN3 in patients with central precocious
puberty in association with the decrease in MKRN3 expression in the medial basal …
puberty in association with the decrease in MKRN3 expression in the medial basal …
Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels
Proopiomelanocortin (POMC) neurons within the hypothalamic arcuate nucleus are vital
anorexigenic neurons. Although both the leptin and insulin receptors are coupled to the …
anorexigenic neurons. Although both the leptin and insulin receptors are coupled to the …
Kisspeptin, neurokinin B, and dynorphin act in the arcuate nucleus to control activity of the GnRH pulse generator in ewes
RL Goodman, SM Hileman, CC Nestor, KL Porter… - …, 2013 - academic.oup.com
Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy)
neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin …
neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin …
[HTML][HTML] Defining a novel leptin–melanocortin–kisspeptin pathway involved in the metabolic control of puberty
Objective Puberty is a key developmental phenomenon highly sensitive to metabolic
modulation. Worrying trends of changes in the timing of puberty have been reported in …
modulation. Worrying trends of changes in the timing of puberty have been reported in …
SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression
MJ Vazquez, CA Toro, JM Castellano… - Nature …, 2018 - nature.com
Puberty is regulated by epigenetic mechanisms and is highly sensitive to metabolic and
nutritional cues. However, the epigenetic pathways mediating the effects of nutrition and …
nutritional cues. However, the epigenetic pathways mediating the effects of nutrition and …