Yeast is a valuable eukaryotic model organism that has evolved many processes conserved
up to humans, yet many protein functions, including certain DNA and protein modifications …

Tyrosine kinases and SH2 (phosphotyrosine recognition) domains have binding specificities
that depend on the amino acid sequence surrounding the target (phospho) tyrosine residue …

Genetically encoded fluorescent protein-based kinase biosensors are a central tool for
illumination of the kinome. The adaptability and versatility of biosensors have allowed for …

Protein kinases play an important role in cellular signaling pathways and their dysregulation
leads to multiple diseases, making kinases prime drug targets. While more than 500 human …

The fidelity of signal transduction requires the binding of regulatory molecules to their
cognate targets. However, the crowded cell interior risks off-target interactions between …

The phosphorylation of proteins affects their functions in extensively documented
circumstances. However, the role of phosphorylation in many interactive networks of …

Sensitivity and plasticity of insulin signaling and glucose uptake in skeletal muscle depends
on determinants such as genetic variation and obesity. We collected muscle biopsies and …

Quantitative multi-omics data are difficult to interpret and visualize due to large volume of
data, complexity among data features, and heterogeneity of information represented by …

Treatment response rates to current anticancer therapies for HER2 overexpressing breast
cancer are limited and are associated with severe adverse drug reactions. Tyrosine kinases …

BCR-ABL is the oncogenic fusion product of tyrosine kinase ABL1 and a highly frequent
driver of acute lymphocytic leukemia (ALL) and chronic myeloid leukemia (CML). The kinase …