Transforming growth factor β (TGF-β) is a pleiotropic cytokine that is widely distributed
throughout the body. Its receptor proteins, TGF-β type I and type II receptors, are also …

The hindlimb and external genitalia of present-day tetrapods are thought to derive from an
ancestral common primordium that evolved to generate a wide diversity of structures …

Long-term hypertension causes excessive vascular remodeling and leads to adverse
cardiovascular events. Balance of ubiquitination and deubiquitination has been linked to …

Testicular germ cell tumours (TGCTs) are the most common malignancy in young men.
Originating from foetal testicular germ cells that fail to differentiate correctly, TGCTs appear …

During gastrulation, the mesendoderm is firstly specified by morphogens such as Nodal, and
then segregates into endoderm and mesoderm in a Nodal concentration-dependent …

Signaling pathways regulate multiple aspects of vertebrate embryonic development.
Members of Transforming Growth Factor β (Tgfβ) superfamily in particular, are involved in …

First Person is a series of interviews with the first authors of a selection of papers published
in Journal of Cell Science, helping early-career researchers promote themselves alongside …

SMAD signaling is crucial for regulating key cellular processes such as differentiation,
proliferation, apoptosis, migration, and extracellular matrix production. The pathway gets …

要旨 DNA シトシンのメチル化 (5mC) は, 哺乳類の胚発生制御に必須なエピジェネティクスの一つ
で, 主に de novo 型の DNMT3A と DNMT3B, 維持型の DNMT1 が担っている. 近年, DNMT1 の …