Solute carrier transporters as potential targets for the treatment of metabolic disease
T Schumann, J König, C Henke, DM Willmes… - Pharmacological …, 2020 - ASPET
The solute carrier (SLC) superfamily comprises more than 400 transport proteins mediating
the influx and efflux of substances such as ions, nucleotides, and sugars across biological …
the influx and efflux of substances such as ions, nucleotides, and sugars across biological …
Invited review: uncoupling proteins and thermoregulation
G Argyropoulos, ME Harper - Journal of applied physiology, 2002 - journals.physiology.org
Energy balance in animals is a metabolic state that exists when total body energy
expenditure equals dietary energy intake. Energy expenditure, or thermogenesis, can be …
expenditure equals dietary energy intake. Energy expenditure, or thermogenesis, can be …
Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes
LT Dalgaard, O Pedersen - Diabetologia, 2001 - Springer
Uncoupling proteins are mitochondrial carrier proteins which are able to dissipate the proton
gradient of the inner mitochondrial membrane. This uncoupling process reduces the amount …
gradient of the inner mitochondrial membrane. This uncoupling process reduces the amount …
UCP2 and UCP3 in muscle controlling body metabolism
P Schrauwen, M Hesselink - Journal of Experimental Biology, 2002 - journals.biologists.com
SUMMARY The uncoupling protein-1 (UCP1) homologues UCP2 and UCP3 are able to
uncouple ATP production from mitochondrial respiration, thereby dissipating energy as heat …
uncouple ATP production from mitochondrial respiration, thereby dissipating energy as heat …
Meta-Analysis Reveals the Association of Common Variants in the Uncoupling Protein (UCP) 1–3 Genes with Body Mass Index Variability
LA Brondani, TS Assmann, BM de Souza, AP Boucas… - PloS one, 2014 - journals.plos.org
Background The relationship between uncoupling protein (UCP) 1–3 polymorphisms and
susceptibility to obesity has been investigated in several genetic studies. However, the …
susceptibility to obesity has been investigated in several genetic studies. However, the …
The human obesity gene map: the 2001 update
T Rankinen, L Pérusse, SJ Weisnagel… - Obesity …, 2002 - Wiley Online Library
This report constitutes the eighth update of the human obesity gene map, incorporating
published results up to the end of October 2001. Evidence from the rodent and human …
published results up to the end of October 2001. Evidence from the rodent and human …
Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC …
A Nieters, N Becker, J Linseisen - European journal of nutrition, 2002 - Springer
Background, aim: In several genes coding for molecules involved in the regulation of body
weight (fat mass) and thermogenesis, polymorphisms have been reported which possibly …
weight (fat mass) and thermogenesis, polymorphisms have been reported which possibly …
Human uncoupling protein‐3 and obesity: an update
MKC Hesselink, M Mensink, P Schrauwen - Obesity research, 2003 - Wiley Online Library
The cloning of the uncoupling protein (UCP) 1 homologs UCP2 and UCP3 has raised
considerable interest in the mechanism. The expression of UCP3 mainly in skeletal muscle …
considerable interest in the mechanism. The expression of UCP3 mainly in skeletal muscle …
Variation in the UCP2 and UCP3genes associates with abdominal obesity and serum lipids: The Finnish Diabetes Prevention Study
T Salopuro, L Pulkkinen, J Lindström… - BMC medical …, 2009 - Springer
Background We explored the associations of three variants in the uncoupling protein 2
(UCP2) gene, one variant in the UCP2-UCP3 intergenic region and five variants in the …
(UCP2) gene, one variant in the UCP2-UCP3 intergenic region and five variants in the …
Functional Polymorphisms of UCP2 and UCP3 Are Associated With a Reduced Prevalence of Diabetic Neuropathy in Patients With Type 1 Diabetes
G Rudofsky Jr, A Schroedter, A Schlotterer… - Diabetes …, 2006 - Am Diabetes Assoc
OBJECTIVE—We studied the association between polymorphisms in the UCP genes and
diabetes complications in patients with type 1 diabetes. RESEARCH DESIGN AND …
diabetes complications in patients with type 1 diabetes. RESEARCH DESIGN AND …