Recent advances in the synthesis of biologically and pharmaceutically active quinoline and its analogues: a review

A Weyesa, E Mulugeta - RSC advances, 2020 - pubs.rsc.org
Recently, quinoline has become an essential heterocyclic compound due to its versatile
applications in the fields of industrial and synthetic organic chemistry. It is a vital scaffold for …

Quinoline‐derivatives as privileged scaffolds for medicinal and pharmaceutical chemists: A comprehensive review

V Yadav, J Reang, V Sharma, J Majeed… - Chemical Biology & …, 2022 - Wiley Online Library
The quinoline scaffolds are privileged for their numerous biological activities in the
pharmaceutical field. This moiety constitutes a well‐known space in several marketed …

Quinoline hydrazide/hydrazone derivatives: Recent insights on antibacterial activity and mechanism of action

S Verma, S Lal, R Narang, K Sudhakar - ChemMedChem, 2023 - Wiley Online Library
Antibiotics are becoming gradually ineffective due to drug resistance, leading to greater
difficulty in the treatment of infectious diseases. Therefore, the development of new chemical …

Comparing and Validating Machine Learning Models for Mycobacterium tuberculosis Drug Discovery

T Lane, DP Russo, KM Zorn, AM Clark… - Molecular …, 2018 - ACS Publications
Tuberculosis is a global health dilemma. In 2016, the WHO reported 10.4 million incidences
and 1.7 million deaths. The need to develop new treatments for those infected with …

Molecular Docking Study for Binding Affinity of 2H‐thiopyrano[2,3‐b]quinoline Derivatives against CB1a

S Sharma, S Singh - Interdisciplinary Perspectives on …, 2023 - Wiley Online Library
Quinoline‐based molecules are major constituents in natural products, active
pharmacophores, and have excellent biological activities. Using 2H‐thiopyrano [2, 3‐b] …

Synthesis, in silico and in vitro analysis of hydrazones as potential antituberculosis agents

BR Thorat, SN Mali, D Rani… - Current Computer-Aided …, 2021 - ingentaconnect.com
Tuberculosis (TB) is a major cause of mortality and illness as reported by the WHO in 2019.
The WHO report also mentioned the fact that about 10.0 million people fell ill with …

Synthesis, admetSAR predictions, DPPH radical scavenging activity, and potent anti-mycobacterial studies of hydrazones of substituted 4-(anilino methyl) …

VJ Desale, SN Mali, BR Thorat… - … Computer-Aided Drug …, 2021 - ingentaconnect.com
Background: For the past several decades, the presence of tuberculosis (TB) is being
remarked as the most common infectious disease leading to mortality. Objective: Hydrazone …

Synthesis, molecular docking, antioxidant, anti-TB, and potent MCF-7 anticancer studies of novel aryl-carbohydrazide analogues

BR Thorat, SN Mali, RR Wagh… - … Computer-Aided Drug …, 2022 - ingentaconnect.com
Background: Hydrazide-hydrazone-based compounds are reported for their wider
pharmacological potentials. Methods: In the present work, we synthesized 10 new Schiff …

Synthesis, antimicrobial activity and molecular docking studies of spiroquinoline-indoline-dione and spiropyrazolo-indoline-dione derivatives

M Gul, E Turk Celikoglu, O Idil, G Tas, E Pelit - Scientific Reports, 2023 - nature.com
Abstract Spiro [benzo [h] quinoline-7, 3′-indoline] diones and spiro [indoline-3, 4′-
pyrazolo [3, 4-b] quinoline] diones were efficiently synthesized via one-pot multi-component …

Quinoline-based anti-oncogenic molecules: Synthesis and biological evaluation

S Sharma, S Singh, D Yadav - Medicinal Chemistry, 2023 - ingentaconnect.com
Quinoline and its analogues are found in various natural products, many of which are active
pharmacophores with significant bioactivities. This article discussed the plethora of …