Normal hearing depends on sound amplification within the mammalian cochlea. The
amplification, without which the auditory system is effectively deaf, can be traced to the …

At specific stages of development, nerve and muscle cells generate spontaneous electrical
activity that is required for normal maturation of intrinsic excitability and synaptic connectivity …

Mechanosensitive sensory hair cells are the linchpin of our senses of hearing and balance.
The inability of the mammalian inner ear to regenerate lost hair cells is the major reason for …

Neurons in the developing auditory system fire bursts of action potentials before the onset of
hearing. This spontaneous activity promotes the survival and maturation of auditory neurons …

Despite recent progress in identifying genes underlying deafness, there are still relatively
few mouse models of specific forms of human deafness. Here we describe the phenotype of …

Developmental changes in electrophysiological membrane properties of mouse cochlear
inner hair cells (IHCs) were studied from just after terminal differentiation up to functional …

1 The expression of K+ currents in mouse outer hair cells (OHCs) was investigated as a
function of developmental age between postnatal day (P) 0 and P26, using whole‐cell patch …

Transient receptor potential (TRP) channels TRPC3 and TRPC6 are expressed in both
sensory neurons and cochlear hair cells. Deletion of TRPC3 or TRPC6 in mice caused no …

Inner ear sensory epithelia contain mechanosensitive hair cells that transmit information to
the brain through innervation with bipolar neurons. Mammalian hair cells do not regenerate …

Sensory‐independent Ca2+ spiking regulates the development of mammalian sensory
systems. In the immature cochlea, inner hair cells (IHCs) fire spontaneous Ca2+ action …