Pathogenic cellular and molecular mediators in lupus nephritis

C Mohan, T Zhang, C Putterman - Nature Reviews Nephrology, 2023 - nature.com
Kidney involvement in patients with systemic lupus erythematosus—lupus nephritis (LN)—is
one of the most important and common clinical manifestations of this disease and occurs in …

Fenfluramine: a plethora of mechanisms?

J Sourbron, L Lagae - Frontiers in pharmacology, 2023 - frontiersin.org
Developmental and epileptic encephalopathies are rare, treatment-resistant epilepsies with
high seizure burden and non-seizure comorbidities. The antiseizure medication (ASM) …

The uPA/uPAR system orchestrates the inflammatory response, vascular homeostasis, and immune system in fibrosis progression

Y Kanno - International Journal of Molecular Sciences, 2023 - mdpi.com
Fibrotic diseases, such as systemic sclerosis (SSc), idiopathic pulmonary fibrosis, renal
fibrosis and liver cirrhosis are characterized by tissue overgrowth due to excessive …

[HTML][HTML] Progress in traditional Chinese medicine and natural extracts for the treatment of lupus nephritis

YJ Wang, YX Li, S Li, W He, ZR Wang, TP Zhan… - Biomedicine & …, 2022 - Elsevier
Lupus nephritis (LN) is an autoimmune disease with multiple system involvement and is also
one of the most serious forms of organ damage in systemic lupus erythematosus (SLE) …

Is Th17-targeted therapy effective in systemic lupus erythematosus?

M Petrić, M Radić - Current issues in molecular biology, 2023 - mdpi.com
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a broad
spectrum of clinical manifestations. The proposed pathophysiological hypotheses of SLE are …

Immunomodulatory activity of mesenchymal stem cells in lupus nephritis: Advances and applications

J Li, M Luo, B Li, Y Lou, Y Zhu, X Bai, B Sun… - Frontiers in …, 2022 - frontiersin.org
Lupus nephritis (LN) is a significant cause of various acute and chronic renal diseases,
which can eventually lead to end-stage renal disease. The pathogenic mechanisms of LN …

Crosstalk between miR-146a and pro-inflammatory cytokines in patients with systemic lupus erythematosus

BA El-Akhras, RM Talaat, SA El-Masry… - International …, 2023 - journals.sagepub.com
microRNA-146a (miR-146a) plays an essential role in immune anomalies and organ injury
of systemic lupus erythematosus (SLE) by regulating the disease's inflammation and …

Decipher the immunopathological mechanisms and set up potential therapeutic strategies for patients with lupus nephritis

CY Tsai, KJ Li, CY Shen, CH Lu, HT Lee… - International Journal of …, 2023 - mdpi.com
Lupus nephritis (LN) is one of the most severe complications in patients with systemic lupus
erythematosus (SLE). Traditionally, LN is regarded as an immune complex (IC) deposition …

Interrelation of T cell cytokines and autoantibodies in systemic lupus erythematosus: A cross-sectional study

FK Alduraibi, KA Sullivan, WW Chatham, HC Hsu… - Clinical …, 2023 - Elsevier
T-helper cytokines interferon gamma (IFNɣ), interleukin 17 (IL-17) and IL-10 impact
systemic lupus erythematosus (SLE) directly and indirectly via modulation of autoAb …

Altered circulating follicular T helper cell subsets and follicular T regulatory cells are indicators of a derailed B cell response in lupus, which could be modified by …

K Szabó, I Jámbor, K Pázmándi, N Nagy… - International Journal of …, 2022 - mdpi.com
Systemic lupus erythematosus (SLE) is characterized by the breakdown of self-tolerance,
the production of high-affinity pathogenic autoantibodies and derailed B cell responses …