Constitutive heterochromatin is responsible for genome repression of DNA enriched in
repetitive sequences, telomeres, and centromeres. During physiological and pathological …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare, autosomal-dominant, and fatal
premature aging syndrome. HGPS is most often derived from a de novo point mutation in the …

Transcription factors (TFs) regulate transcription of their target genes by identifying and
binding to regulatory regions of the genome among billions of potential non-specific decoy …

The process in which locally confined epithelial malignancies progressively evolve into
invasive cancers is often promoted by unjamming, a phase transition from a solid-like to a …

Background Point mutations in histone variant H3. 3 (H3. 3K27M, H3. 3G34R) and the H3. 3-
specific ATRX/DAXX chaperone complex are frequent events in pediatric gliomas. These …

Detecting and tracking multiple moving objects in a video is a challenging task. For living
cells, the task becomes even more arduous as cells change their morphology over time, can …

Background: Time-lapse microscopy imaging is a key approach for an increasing number of
biological and biomedical studies to observe the dynamic behavior of cells over time which …

Long interspersed nuclear elements (LINEs) play essential roles in shaping chromatin
states, while the factors that cooperate with LINEs and their roles in higher‐order chromatin …

Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the
genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is …

Studies of laminopathy-based progeria offer insights into aging-associated diseases and
highlight the role of LMNA in chromatin organization. Mandibuloacral dysplasia type A …