International Union of Basic and Clinical Pharmacology. CVI: GABAA receptor subtype-and function-selective ligands: key issues in translation to humans
W Sieghart, MM Savić, EH Ohlstein - Pharmacological reviews, 2018 - Elsevier
GABA A receptors are the major inhibitory transmitter receptors in the brain. They are ligand-
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …
Electrophysiology of ionotropic GABA receptors
E Sallard, D Letourneur, P Legendre - Cellular and Molecular Life …, 2021 - Springer
GABAA receptors are ligand-gated chloride channels and ionotropic receptors of GABA, the
main inhibitory neurotransmitter in vertebrates. In this review, we discuss the major and …
main inhibitory neurotransmitter in vertebrates. In this review, we discuss the major and …
Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities
Abstract γ-Aminobutyric acid type A (GABAA) receptors are pentameric ligand-gated ion
channels abundant in the central nervous system and are prolific drug targets for treating …
channels abundant in the central nervous system and are prolific drug targets for treating …
Neural signatures of sleep in zebrafish
Slow-wave sleep and rapid eye movement (or paradoxical) sleep have been found in
mammals, birds and lizards, but it is unclear whether these neuronal signatures are found in …
mammals, birds and lizards, but it is unclear whether these neuronal signatures are found in …
GABAA receptors and the diversity in their structure and pharmacology
Abstract GABA A receptors (GABA A Rs) are a class of ligand-gated ion channels with high
physiological and therapeutic significance. In the brain, these pentameric receptors occur …
physiological and therapeutic significance. In the brain, these pentameric receptors occur …
Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions
The function and pharmacology of γ-aminobutyric acid type A receptors (GABAARs) are of
great physiological and clinical importance and have long been thought to be determined by …
great physiological and clinical importance and have long been thought to be determined by …
Sleep disturbances after general anesthesia: current perspectives
M Luo, B Song, J Zhu - Frontiers in neurology, 2020 - frontiersin.org
The purpose of this article is to review (1) sleep mechanism under general anesthesia,
harmful effects of postoperative sleep disturbances;(2) risk factors associated with …
harmful effects of postoperative sleep disturbances;(2) risk factors associated with …
Reducing GABAA-mediated inhibition improves forelimb motor function after focal cortical stroke in mice
A deeper understanding of post-stroke plasticity is critical to devise more effective
pharmacological and rehabilitative treatments. The GABAergic system is one of the key …
pharmacological and rehabilitative treatments. The GABAergic system is one of the key …
A systematic scoping review of the effects of central nervous system active drugs on sleep spindles and sleep-dependent memory consolidation
CWY Leong, JWS Leow, RR Grunstein… - Sleep Medicine …, 2022 - Elsevier
Sleep spindles are key electroencephalogram (EEG) oscillatory events that occur during
non-rapid eye movement (NREM) sleep. Deficits in sleep spindles are present in …
non-rapid eye movement (NREM) sleep. Deficits in sleep spindles are present in …
GABA signalling in human pancreatic islets
Z Jin, SV Korol - Frontiers in Endocrinology, 2023 - frontiersin.org
The pancreatic islets are essential microorgans controlling the glucose level in the blood.
The islets consist of different cell types which communicate with each other by means of auto …
The islets consist of different cell types which communicate with each other by means of auto …